Synthesis of Novel β,β-Bridged Porphyrin Dimers and Investigation of Their Photosensitive Activity

Abstract

Abstract:

Four novel β,β-bridged porphyrin dimers were designed and synthesized. The monomers are 2-(1-hydroxynaphthyl)-5,10,15,20-tetraphenylporphyrin or its Cu(Ⅱ), Ni(Ⅱ), Zn(Ⅱ) complexes. The abilities of singlet oxygen production for the porphyrin dimer and its Ni(Ⅱ), Zn(Ⅱ) complexes under photo irradiation were studied with DPBF as the quencher. The cleavage ability of pBR322 DNA(by gel electrophoresis) and antibacterial activity on Staphylococcus aureus(ATCC 25923) of the novel porphyrin dimers were tested under photo irradiation and in dark. The results show that porphyrin dimers exhibit high photocytotoxicity against Staphylococcus aureus.

Key words: Porphyrin dimer, pBR322 DNA, Antibacterial, Photosensitive activity

TrendMD:

HUANG Qi-Mao, XIAO Xin, PAN Zhi-Quan*, LI Zhi-Yuan, DENG Peng-Xing, ZHANG Ying. Synthesis of Novel β,β-Bridged Porphyrin Dimers and Investigation of Their Photosensitive Activity[J]. Chem. J. Chinese Universities, 2009, 30(5): 923.

References

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