Synthesises, Structures and Antibacterial Activities of a Series of Rare Earth Nitrogen Heterocyclic Complexes†

doi:10.7503/cjcu20180733

Abstract

Abstract:

A series of rare earth metal complexes, [Ln(IAA)₂(phen)₂]·(NO₃)[Ln=Ce(1), Gd(2), Tb(3), Dy(4), Ho(5). HIAA=indole acetic acid, phen=1,10-phenanthroline], was synthesized via the solution synthesis method at room temperature. The structures of the complexes were characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, X-ray single crystal diffraction and powder polycrystalline diffraction. Structural analyses show that complex 2 has a supramolecular network structure and its 2D network structure is formed through intermolecular hydrogen bonds. The central metal Gd(Ⅲ) is nine-coordinated with a single-capped quadrilateral inverse prism geometry. In addition, the antibacterial activity of the five complexes was studied, and the structure-activity relationship between antibacterial activity and composition of complexes was analysized.

Key words: Rare earth complex, Indole acetic acid, 1,10-Phenanthroline, Crystal structure, Antibacterial activity

CLC Number:

O614

TrendMD:

LI Bing,WANG Xuemin,BAI Fengying,LIU Shuqing. Synthesises, Structures and Antibacterial Activities of a Series of Rare Earth Nitrogen Heterocyclic Complexes^†[J]. Chem. J. Chinese Universities, 2019, 40(4): 632.

Figures/Tables 5

Fig.1 Pictures of pathogenic bacteria S.A.(A), E.C.(B), P.A.(C), C.A.(D), B.S.(E)

Table 1 Crystal data and structure refinement for complex 2

Formula	C₄₄H₃₂N₇O₇Gd	D_c/(g·cm^-3)	1.477
Molecular weight	928.02	F(000)	1860
Crystal system	Monoclinic	μ(Mo Kα)/mm^-1	1.647
Space group	P2(1)/n	θ range/(°)	1.67—28.25
a/nm	1.3501(9)	Reflections collected	25661
b/nm	1.3404(9)	Independent reflections[I>2σ(I)]	9477
c/nm	2.3208(16)	Parameter	532
α/(°)	90	Goodness of fit	1.090
β/(°)	96.4260(10)	R^a(R^b)	0.0741(0.1145)^b
γ/(°)	90	w $R 2 a$ ( $R 2 b$ )	0.1981(0.2259)^b
V/nm³	4.1739(5)	Δρ/(e·nm^-3)	1626, -611
Z	4

Table 1 Crystal data and structure refinement for complex 2

Formula	C₄₄H₃₂N₇O₇Gd	D_c/(g·cm^-3)	1.477
Molecular weight	928.02	F(000)	1860
Crystal system	Monoclinic	μ(Mo Kα)/mm^-1	1.647
Space group	P2(1)/n	θ range/(°)	1.67—28.25
a/nm	1.3501(9)	Reflections collected	25661
b/nm	1.3404(9)	Independent reflections[I>2σ(I)]	9477
c/nm	2.3208(16)	Parameter	532
α/(°)	90	Goodness of fit	1.090
β/(°)	96.4260(10)	R^a(R^b)	0.0741(0.1145)^b
γ/(°)	90	w $R 2 a$ ( $R 2 b$ )	0.1981(0.2259)^b
V/nm³	4.1739(5)	Δρ/(e·nm^-3)	1626, -611
Z	4

Fig.2 Crystal structure of complex 2(A) Coordination environment of the Gd(Ⅲ) ion(dimer configuration); (B) single-capped quadrilateral inverse prism geometry of Cd(Ⅲ); (C) coordination mode of ligand 1,10-phenanthroline; (D) coordination mode of ligand indole acetic acid; (E) 1D hydrogen-bonded chain along b axis(#1: -x+1, -y+1, -z+1); (F) 2D hydrogen bond network on the surface of bc(#2: 3/2-x, -1/2+y, 1/2-z). All H atoms except for the hydrogen bonds are omitted for clarity.

Fig.3 Comparison of antibacterial rings of complexes 1—5 and phen against S.A.

Fig.4 Linear relationship between concentration of complexes 1—5, phen and diameter of bacteriostatic ring against S.A.

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