Triterpenoids from the Sponge Stelletta sp.Collected from the South China Sea

Chem. J. Chinese Universities ›› 2005, Vol. 26 ›› Issue (12): 2270.

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Triterpenoids from the Sponge Stelletta sp.Collected from the South China Sea

LAN Wen-Jian¹,LIN Cui-Wu²,SU Jing-Yu³,ZENG Long-Mei^3*

1.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510080,China;
2.School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China;
3.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China

Received:2004-12-28 Online:1905-03-14 Published:1905-03-14
Contact: ZENG Long-Mei;E-mail:ceszlm@zsu.edu.cn

Abstract

Abstract:

Three isomalabaricane and malabaricane triterpenoids(1-3) were isolated from the sponge Stelletta sp.collected from Weizhou Island,Guangxi Province.The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis.All ¹H NMR and ¹³C NMR signals of compound 1 were assigned for the first time on the basis of HMQC,¹H-¹H COSY and HMBC experiment.Antitumor assay exhibits that compounds 1,2 and 3 have a significant antitumor activity against P388 tumor cell lines with ED₅₀ values 0.01,0.5,1.0 μg/mL,respectively.

Key words: Sponge; Stelletta sp.; Triterpenoid; Antitumor activity, Sponge, Stelletta sp., Triterpenoid, Antitumor activity

CLC Number:

O629.61

TrendMD:

LAN Wen-Jian,LIN Cui-Wu,SU Jing-Yu,ZENG Long-Mei. Triterpenoids from the Sponge Stelletta sp.Collected from the South China Sea[J]. Chem. J. Chinese Universities, 2005, 26(12): 2270.

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Triterpenoids from the Sponge Stelletta sp.Collected from the South China Sea

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