Preparation and Characterization of Fast-responsive Porous Poly(N-isopropylacrylamide-co-acrylic Acid) Hydrogels

Abstract

Abstract: Temperature-sensitive porous poly(N-isopropylacrylamide-co-acrylic acid)[P(NIPA-co-AAc)] hydrogels with fast responsive properties were prepared by radical copolymerization in aqueous solution via using PEG6000 as the pore-forming agent. In comparison to the conventional gels, the porous P(NIPA-co-AAc) gels exhibited faster response rate to temperature changes and higher swelling ratios at the temperature below lower critical solution temperature(LCST), which can be attributed to the porous structure formed in the process of the polymerization/crosslinking. With increasing the contents of AAc in the gel matrixs, the LCST increased, which was caused by the high hydrophilicity of AAC component. The results suggest the potential of these novel porous hydrogels for the controlled release of drugs, especially for macromolecular drugs.

Key words: Temperature-sensitivity, N-Isopropylacrylamide, Hydrogel, Macropore, Fast responsivity

CLC Number:

O633

TrendMD:

ZHANG Jian-Tao, HUANG Shi-Wen, WANG Lu-Ling, ZHUO Ren-Xi . Preparation and Characterization of Fast-responsive Porous Poly(N-isopropylacrylamide-co-acrylic Acid) Hydrogels[J]. Chem. J. Chinese Universities, 2004, 25(12): 2370.

References

[1] 　Zhang X.Z.,Yang Y.Y.,W ang F.J.et al..L angm uir[J],2002,18:2013—2018 [2] 　Zhang J.T.,Cheng S.X.,H uang S.W.et al..M acromo .lR ap id.Com unn.[J],2003,24:447—451 [3] 　Shan tha K.L.,H arding D.R.K..In t.J.Pharm.[J],2000,207:65—704 [4] 　ZHAN G X ian-Zheng(张先正),ZHUO R en-X i(卓仁禧).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],2000,21(8):1309—1311 [5] 　ZHAN G X ian-Zheng(张先正),ZHUO R en-X i(卓仁禧).Chem.J.Ch inese U n iversities(高等学校化学学报)[J],2000,21(11):1776—1778 [6] 　Sch ild H.G..P rog.Po lym.Sci.[J],1992,17:163—249 [7] 　H irokaw a Y.,T anaka T..J.Chem.Phys.[J],1984,81:6379—6380 [8] 　Zhang X.Z.,Zhuo R.X.,Cui J.Z.et al..In t.J.Pharm.[J],2002,235:43—50 [9] 　L iu F.,T ao G.L.,Zhuo R.X..Po lym.J.[J],1993,25:561—567 [10] 　Kurisaw a M.,Yokoyam a M.,O kano T..J.Con tro .lR e.l[J],2000,69:127—137 [11] 　Sh ibayam a M.,Ikk i F.,Inamo to S.et al..J.Chem.Phys.[J],1996,105:4358—4366 [12] 　M a C.S.,Zhang W.M.,C iszkow ska M..J.Phys.Chem.B[J],2001,105:10446—10452 [13] 　Zhang X.Z.,Zhuo R.X..Eur.Po lym.J.[J],2000,36:2301—2303 [14] 　Zhuo R.X.,L iW..J.Po lym.Sc.iPart A:Po lym.Chem.[J],2003,41:152—159 [15] 　Feil H.,Bae Y.H.,Feijen J.et al..M acromo lecules[J],1993,26:2496—2500 [16] 　Zhang J.T.,Cheng S.X.,Zhuo R.X..J.Po lym.Sc.iPart A:Po lym.Chem.[J],2003,41:2390—2392 [17] 　H iro se H.,Sh ibayam a M..M acromo lecules[J],1998,31:5336—5342 [18] 　M atsuo E.S.,T anaka T..J.Chem.Phys.[J],1988,89:1695—1703 [19] 　Sh ibayam a M.,N agai K..M acromo lecules[J],1999,32:7461—7468 [20] 　Zhang J.T.,Cheng S.X.,Zhuo R.X..Co llo id Po lym.Sc.i[J],2003,281:580—583 [21] 　Cheng S.X.,Zhang J.T.,Zhuo R.X..J.B iom ed.M ater.R es.[J],2003,67A:96—103