Interaction Between DNA and a Novel Ferrocenyl-containing Ruthenium(Ⅱ) Polypyridyl Complex

Abstract

Abstract: A novel ruthenium polypyridyl complex of [Ru(bpy)₂(FcIP)](PF₆)₂(bpy=2,2′-bipyridine, FcIP=2-ferrocenyl-imidazo[4,5-f]-1, 10-phenanthroline) was synthesized and characterized by elementary analysis and ¹H NMR. The binding of the complex to calf thymus(ct) DNA was investigated with absorption and luminescence spectroscopy titrations, steady-state emission quenching, and viscosity measurements. The results suggest that the complex acted as a ct-DNA intercalator with an intrinsic binding constant of (2.0±0.4)×10 ⁵L/mol in buffered 50 mmol/L NaCl.

Key words: DNA, Ruthenium(Ⅱ) complex, Ferrocene

CLC Number:

O641.3

TrendMD:

HAN Mei-Jiao, WANG Ke-Zhi, LÜ Yuan-Yuan, GAO Li-Hua . Interaction Between DNA and a Novel Ferrocenyl-containing Ruthenium(Ⅱ) Polypyridyl Complex[J]. Chem. J. Chinese Universities, 2004, 25(12): 2221.

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Interaction Between DNA and a Novel Ferrocenyl-containing Ruthenium(Ⅱ) Polypyridyl Complex

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