Synthesis of New Multifunctional Chiral C4 Building Blocks from D-Erythorbic Acid

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (6): 1094.

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Synthesis of New Multifunctional Chiral C₄ Building Blocks from D-Erythorbic Acid

LI Ming-Xia¹, WANG Yan-Ming², CHEN Ru-Yu¹

1. Research Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, China;
2. Pittsburgh University Medical Center, Pittsburgh, PA 15213, USA

Received:2001-02-23 Online:2002-06-24 Published:2002-06-24

Abstract

Abstract: Compounds 4 and 5 which were new selectively protected and multifunctional chiral C₄ building blocks were prepared conveniently from commercially available D-erythorbic acid in no more than three steps with satisfied yields. Since compound 4 and compound 5 are densely functionalized and rich in stereochemistry, they are useful chiral building blocks in asymmetric synthesis.

Key words: D-Erythorbic acid, Multifunctional group, Chiral, C-4 building block

CLC Number:

O621

TrendMD:

LI Ming-Xia, WANG Yan-Ming, CHEN Ru-Yu . Synthesis of New Multifunctional Chiral C₄ Building Blocks from D-Erythorbic Acid[J]. Chem. J. Chinese Universities, 2002, 23(6): 1094.

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Synthesis of New Multifunctional Chiral C₄ Building Blocks from D-Erythorbic Acid

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