Determination of Activity of Antioxygenation of Glutathione by the "Probe" of the Lactic Acid(LA)-Acetone(Act)-BrO3--Mn2+-H2SO4 Oscillating System

Abstract

Abstract: In our experiment, we applied APPtechnique to study of the perturbation of glutathione(GSH) which is an important antioxidant in vivo on the lactic acid(LA) Acetone(Act) BrO₃^--Mn²⁺-H₂SO₄ oscillating reaction. And we determinate the activity of antioxygenation of GSHby the "probe" of this oscillating system. Influence of experiment variables were investigated, and can be as a base of quantitative analysis. The linear range lies between 1.50×10^-7-2.25×10^-5mol/L, and the determination limit is 2.20×10^-9mol/L. And the precision and throughput were also quite good(1.35% as RSD, and 6-9 samples/h, respctively). Some aspects of the potential mechanism of action GSHon the oscillating systems are discussed.

Key words: Glutathione, Lactic acid, APP technique, Antioxygenatic activity

CLC Number:

O652.7

TrendMD:

YANG Shu-Tao, GAN Nan-Qin, LIN Zhi-Xin, CAI Ru-Xiu . Determination of Activity of Antioxygenation of Glutathione by the "Probe" of the Lactic Acid(LA)-Acetone(Act)-BrO₃^--Mn²⁺-H₂SO₄ Oscillating System[J]. Chem. J. Chinese Universities, 2002, 23(6): 1026.

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Determination of Activity of Antioxygenation of Glutathione by the "Probe" of the Lactic Acid(LA)-Acetone(Act)-BrO₃^--Mn²⁺-H₂SO₄ Oscillating System

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