Studies on the Reaction of Aromatic Aldehyde with Active Methylene Compound under Microwave Irradiation

Abstract

Abstract: A series of 4-aryl-7,7-dimethyl-2, 5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline (4) and 4-aryl-7,7-dimethyl-5-oxo-3,4,5,6,7,8-hexahydrocoumarin (5) were synthesized from aromatic aldehydes (1), 5,5-dimethyl-1,3-cyclohexandione (2) and isopropylidene malonate (3) by the condensation, addition, cyclization and elimination reactions under microwave irradiation under different conditions. The reactions were completed in 3-5 min with good yields. The structure of the products were established on IR, ¹H NMR, elemental analysis and X-ray diffraction.

Key words: Aromatic aldehyde, Active methylene compound, Microwave, Crystal, X-ray diffraction

CLC Number:

O626.3

TrendMD:

TU Shu-Jiang, DENG Xu, ZHOU Jian-Feng, SUN Bai-Wang, FENG Jun-Cai  . Studies on the Reaction of Aromatic Aldehyde with Active Methylene Compound under Microwave Irradiation[J]. Chem. J. Chinese Universities, 2002, 23(2): 222.

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Studies on the Reaction of Aromatic Aldehyde with Active Methylene Compound under Microwave Irradiation

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