The Influence of Water Molecules in the Structure-activity Relationship Study of Sulfonylurea Molecules

Abstract

Abstract: A study of some sulfonylurea molecules with consideration of water molecules as its solvent was undertaken. The influence of the water molecules on the structure-activity relationship of the 35 sulfonylurea molecules was discussed . By supper-imposition of structural sulfonyl molecules, a molecular RMS was correlated with pI₅0, which denotes that the configuration difference in water solution is one of the reasons which causes the difference in bioactivity.

Key words: Solvent, Water, Sulfonylurea, ALS enzyme, Structure-activity relationship

CLC Number:

O626

TrendMD:

MA Yi, LIU Jie, LI Zheng-Ming . The Influence of Water Molecules in the Structure-activity Relationship Study of Sulfonylurea Molecules[J]. Chem. J. Chinese Universities, 2000, 21(1): 85.

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The Influence of Water Molecules in the Structure-activity Relationship Study of Sulfonylurea Molecules

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