Synthesis and Invitro Bloodcompatibility of Polyurethane Modified by Amino Acid

Abstract

Abstract: Anew reactive graft copolymer, polyurethane-graft-w-propyl sodium sulfonatepoly(ethylene glycol)(PEU-g-PEO-SO₃^-Na⁺), was synthesized by PTMG-g-PEO-SO₃^-Na⁺, MDI and 1,4-butanedioL IN two steps. Two amino acids (L-lysine and L-tyrosine) were covalently attached to the copolymer after converting the sulfonate group to sulfonyl chloride. The structure of the resuting polyurethanes were characterized by IRand UV. The polyurethane modified by L-lysine and L-tyrosine can resist both platelet adhesion and thromb formation.

Key words: Polyurethane, Lysine, Blood-compatibility

CLC Number:

O631.3

TrendMD:

JI Jian, JI Ren-Tian, QIU Yong-Xing, CHEN Bao-Lin, FENG Lin-Xian. Synthesis and Invitro Bloodcompatibility of Polyurethane Modified by Amino Acid[J]. Chem. J. Chinese Universities, 1999, 20(6): 974.

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Synthesis and Invitro Bloodcompatibility of Polyurethane Modified by Amino Acid

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