The Synthesis and Properties of N-(β-Ttiphenylgermalyl) propionyl-α-amino-methylphosphonates

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (6): 892.

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The Synthesis and Properties of N-(β-Ttiphenylgermalyl) propionyl-α-amino-methylphosphonates

CHEN Ru-Yu, MAO Li-Juan

Research Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071

Received:1994-05-02 Revised:1995-03-08 Online:1995-06-24 Published:1995-06-24

Abstract

Abstract: In this paper,two series of N-(β-triphenylgermanyl)propionyl-α-aminomethylphosphonates have been synthesized and both conditions and mechanism of the condensation reaction of sterically hindered α-aminomethylphosphonate with β-triphenylgermanyl propionic acid were studied. Preliminary bioassays indicate that the title compounds compared with corresponding α-amino-methylphosphonates have more significant antitumor and anti-TMV properties.

Key words: α-Amino-methylphosphonate, β-Triphenylgermanyl, propionic, acid, Condensation, reaction, Antitumor, activity, Structure, confirmation

TrendMD:

CHEN Ru-Yu, MAO Li-Juan. The Synthesis and Properties of N-(β-Ttiphenylgermalyl) propionyl-α-amino-methylphosphonates[J]. Chem. J. Chinese Universities, 1995, 16(6): 892.

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The Synthesis and Properties of N-(β-Ttiphenylgermalyl) propionyl-α-amino-methylphosphonates

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