Synthesis of Crosslinked Polyphosphates and Drug Release

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (10): 1633.

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Synthesis of Crosslinked Polyphosphates and Drug Release

LUO Yi¹, ZHUO Ren-xi², FAN Chang-Lie²

1. Department of Chemistry, Peking University, Beijing, 100871;
2. Department of Chemistry, Wuhan University, 430072

Received:1994-10-14 Revised:1995-02-21 Online:1995-10-24 Published:1995-10-24

Abstract

Abstract: Ring-opening polymerizations of 2-hydro-2-oxo-3,2-dioxa-phospholan and/or 2-hydro-2-oxo-1,3,2-dioxaphosphorinane were studied using(i-Bu₃)Al as initiator. After chlorination and hydrolysis, crosslinked polymers were obtained.The in vitro release of 5-fluorouracil from its single-matrix pellets,double-layered pellets and sandwich pellet with the crosslinked polyphosphates as drug carriers were carried out in phosphate buffer solution(pH7.4)at 37℃. Sustained release from the sandwich pellet was more controlled than that from the single-matrix pellets and double-layered pellets.

Key words: Crosslinked polyphosphate, 5-Fluorouracil, Drug release

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LUO Yi, ZHUO Ren-xi, FAN Chang-Lie. Synthesis of Crosslinked Polyphosphates and Drug Release[J]. Chem. J. Chinese Universities, 1995, 16(10): 1633.

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Synthesis of Crosslinked Polyphosphates and Drug Release

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