Voltammetric Determination of 5-Hydroxyindol-acetic Acid, Uric Acid and Homovanillic Acid in Animal Brain with Carbon Fiber Electrodes

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (10): 1374.

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Voltammetric Determination of 5-Hydroxyindol-acetic Acid, Uric Acid and Homovanillic Acid in Animal Brain with Carbon Fiber Electrodes

PENG Tu-Zhi¹, WANG Guo-Shun¹, LI Hui-Ping¹, LIU Guo-Qing², CAO Yu-Ping²

1. Department of Chemistry, Ilangzhou University, Ilangzhou, 310028;
2. Department of Pharmacology, China Pharmaceutical University, Nanjing

Received:1992-10-12 Revised:1993-04-15 Online:1993-10-24 Published:1993-10-24

Abstract

Abstract: An simple electrochemical pretreatment has been used to active carbon fiber electrodes for in vivo determination.In rat brain, there were four well-defined semi-differential voltammet-ric peaks.The peak at 0.36 Vwas combined by oxidative current of 5-HIAAand UA, 5-HIAAwas about 80% and UAabout 20%.The oxidation of HVAformed the peak at 0.54 V.The concentrations in brain extracellular fluid were determined, 5-HIAA, 3×10^-6 mol/L; UA, 9×10^-5 mol/Land HVA 8×10^-6 mol/L.

Key words: Carbon fiber electrode, Semi-differential voltammetry, Neurotransmitter, Uric acid

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PENG Tu-Zhi, WANG Guo-Shun, LI Hui-Ping, LIU Guo-Qing, CAO Yu-Ping. Voltammetric Determination of 5-Hydroxyindol-acetic Acid, Uric Acid and Homovanillic Acid in Animal Brain with Carbon Fiber Electrodes[J]. Chem. J. Chinese Universities, 1993, 14(10): 1374.

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Voltammetric Determination of 5-Hydroxyindol-acetic Acid, Uric Acid and Homovanillic Acid in Animal Brain with Carbon Fiber Electrodes

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