Chem. J. Chinese Universities ›› 2019, Vol. 40 ›› Issue (2): 240.doi: 10.7503/cjcu20180519

• Analytical Chemistry • Previous Articles     Next Articles

Uric Acid Biosensor Based on Ni Wire Modified with NiO Nanosheets

JIA Hongliang, ZHAO Jianwei*(), QIN Lirong, ZHAO Min   

  1. School of Physical Science and Technology, Southwest University, Chongqing 400715, China
  • Received:2018-07-24 Online:2019-02-10 Published:2018-11-16
  • Contact: ZHAO Jianwei E-mail:zhaojw@swu.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No.11204246) and the Fundamental Research Funds for the Central Universities, China(No.XDJK2018B033)

Abstract:

Ni wire modified with NiO nanosheets was synthesized by hydro-thermal method accompanied with heat treatment at high-temperature. The characterized results revealed that these NiO nanosheets grew uniformly on the surface of the Ni wire, with a size of several hundreds of nanometers and a thickness of about ten nanometers. Electrochemical experiments showed that the Ni wire modified with NiO nanosheets could be used as a kind of good material for immobilization of uricase to fabricate an efficient uric acid biosensor. Sensitivity of the prepared biosensor was found to be 821.4 μA/(mmol·cm2). The linear range for the detection was 1—900 μmol/L. The detection limit was 0.1 μmol/L. These results indicate that the Ni wire modified with NiO nanosheets is a new platform for the construction of biosensors.

Key words: Ni wire, Nanostructures, Hydrothermal method, Uric Acid, Biosensor

CLC Number: 

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