Chem. J. Chinese Universities ›› 1989, Vol. 10 ›› Issue (4): 345.

• Articles • Previous Articles     Next Articles

The Chelating Competition for Bovine Serum Albumin Bound Ni(Ⅱ)

Li Rongchang, Gao Jingmin, Wu Hongyan, Wang Kui   

  1. Department of Inorganic Chemistry, Beijing Mediual University, Beijing
  • Received:1987-09-22 Online:1989-04-24 Published:1989-04-24

Abstract: The mobilizing powers of thirteen chelating agents for Bovine Albumin Bound Ni(Ⅱ) (BSANi(Ⅱ) were studied by gel chromatographic method. The experimental results show that the polyaminopolycarboxylate type chelators, especially DTPA and NTA are stronger mobilizing ligands than the mercapto chelators. The kinetics of these reactions have been studied at pH=7.4, and the mechanism has been elucidated. The reactions of His and EDTA with BSANi(Ⅱ) were found following the dissociation mechanism, but iminodiace-tic acid (IDA) and DTPA, association mechanism. The kinetic parameters were determined by dialysis method. The potentiality of the chelators as the agents to accelerate the excretion of Ni is discussed on the basis of the F.

Key words: Albumin, Nickel, Chelating competition

TrendMD: