Chem. J. Chinese Universities ›› 1988, Vol. 9 ›› Issue (11): 1193.

• Articles • Previous Articles     Next Articles

Resolution of Cis-Chrysanthemic Acid With Quinine

Tang Chuchi, Chen Junran, LI Gungren, Shao Ruilian, Jin Guiyu   

  1. Institute of Elemento-Organio Chemistry, Nankai University, Tianjin
  • Received:1987-06-02 Online:1988-11-24 Published:1988-11-24

Abstract: (±)-Cis-chrysanthemic acid 1 was resolved into (+)-1R-1 and(-)-1S-1 via the diastereomeric salts by using quinine as resolution reagent. Thus,the mixture of equimolar amount of (±)-1 and quinine was heated in EtOH-H2O(4:1 V/V) to have been solved cmpletely and was allowed to standundisturbed in a water bath at, 43~35℃ for 12~16h. The fine needles obtainedwere recrystallized.

Key words: Cis-chrysanthemic acid, Quinine, Resolution

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