Hypoxia Activated Chemotherapy Drug AQ4N and Carbon Dots Self-assembly for Chemotherapy Combined with Sonodynamic Therapy of Tumors

doi:10.7503/cjcu20240489

Chem. J. Chinese Universities ›› 2025, Vol. 46 ›› Issue (6): 20240489.doi: 10.7503/cjcu20240489

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Hypoxia Activated Chemotherapy Drug AQ4N and Carbon Dots Self-assembly for Chemotherapy Combined with Sonodynamic Therapy of Tumors

PANG E¹, TANG Yuanyu¹, ZHAO Shaojing¹, CHENG Qiang¹, WANG Chen¹, CHEN Jianmin²(), LAN Minhuan¹()

^1.Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science，College of Chemistry and Chemical Engineering，Central South University，Changsha 410083，China
^2.School of Pharmacy，Putian University，Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine，Fujian Province University，Putian 351100，China

Received:2024-10-31 Online:2025-06-10 Published:2024-12-09
Contact: CHEN Jianmin, LAN Minhuan E-mail:chenjianmin1985@sina.com;minhuanlan@csu.edu.cn
Supported by:
the National Key Research and Development Program of China(2022YFA1207600);the National Natural Science Foundation of China(62375289);the Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University), Fujian Province University, China(PALM 202201)

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Abstract

Abstract:

A red fluorescent carbon dots（CDs） with sonodynamic activity were synthesized， and the CDs@AQ4N nano-assemblies were prepared by assembling the hypoxia-activating drug AQ4N， with CDs via electrostatic interaction， hydrogen bonding， and π-π interactions. CDs@AQ4N could effectively generate singlet oxygen（¹O₂） for sonodynamic therapy（SDT） of cancer cells. Moreover， the depletion of intra-tumor oxygen during SDT further exacerbated the tumor hypoxia， which activated AQ4N and converted it into cytotoxic AQ4， enabling fluorescence-imaging-guided combination of SDT and chemotherapy for the treatment of mice tumors. The excellent biosafety of CDs@AQ4N was confirmed by mouse major organ sections， blood routine and blood biochemical analyses.

Key words: Carbon dots, Hypoxic activation, Sonodynamic therapy, Chemotherapy, Synergistic therapy

CLC Number:

O615.4

TrendMD:

PANG E, TANG Yuanyu, ZHAO Shaojing, CHENG Qiang, WANG Chen, CHEN Jianmin, LAN Minhuan. Hypoxia Activated Chemotherapy Drug AQ4N and Carbon Dots Self-assembly for Chemotherapy Combined with Sonodynamic Therapy of Tumors[J]. Chem. J. Chinese Universities, 2025, 46(6): 20240489.

Figures/Tables 6

References 25

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Hypoxia Activated Chemotherapy Drug AQ4N and Carbon Dots Self-assembly for Chemotherapy Combined with Sonodynamic Therapy of Tumors

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