Active shrinkage hydrogel based on red emissive carbon dots photosensitizers for bacterial infected wound healing

doi:10.7503/cjcu20240409

Chem. J. Chinese Universities

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Active shrinkage hydrogel based on red emissive carbon dots photosensitizers for bacterial infected wound healing

HAO Yongliang^1,2, LI Jian^1,2, WANG Zehua^1,2, GE Jiechao^1,2

1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials，Technical Institute of Physics and Chemistry，Chinese Academy of Sciences
2. School of Future Technology，University of Chinese Academy of Sciences

Received:2024-08-30 Revised:2024-09-23 Online:2024-10-08 Published:2024-10-08
Contact: Jiechao Ge E-mail:jchge2010@mail.ipc.ac.cn
Supported by:
National Natural Science Foundation of China (No. 52272052) and the Project of the National Key Research and Development Program of China (No. 2022YFA1207600)

Abstract

Abstract: An active shrinkage hydrogel based on red emissive carbon dots (CDs) photosensitizers (PSs) was developed for bacterial infected wound healing. The hydrogel was prepared by using N-isopropylacrylamide (NIPAM), sodium alginate (SA) and CDs PSs as precursors through free radical polymerization and calcium ion cross-linking. The hydrogel could release CDs PSs at body temperature (37 ℃) due to the active shrinkage of hydrogel. Upon light irradiation, the released CDs PSs can generate singlet oxygen to kills bacteria effectively in the wound site leading to the rapid wound healing. In vitro and in vivo results suggest that the developed active shrinkage hydrogel have good drug release, photodynamic antibacterial effects and the ability to accelerate wound healing, thus providing a new type of hydrogel for clinical wound management.

Key words: Carbon dots, Photodynamic antibacterial, Hydrogel, Wound healing

CLC Number:

O636

TrendMD:

HAO Yongliang, LI Jian, WANG Zehua, GE Jiechao. Active shrinkage hydrogel based on red emissive carbon dots photosensitizers for bacterial infected wound healing[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20240409.

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Active shrinkage hydrogel based on red emissive carbon dots photosensitizers for bacterial infected wound healing

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