Antioxidative Carbon Dots Improving Acute Liver Injury Induced by Acetaminophen

doi:10.7503/cjcu20240130

Chem. J. Chinese Universities

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Antioxidative Carbon Dots Improving Acute Liver Injury Induced by Acetaminophen

LI Yan, CAI Hao, BI Hong

College of Materials Science and Engineering, Anhui University, Hefei 230601, China

Received:2024-03-20 Revised:2024-05-07 Online:2024-05-15 Published:2024-05-15
Contact: BI Hong E-mail:bihong@ahu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No. 52172033) and the National Key Research and Development Program of China(No. 2021YFA1600202).

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Abstract

Abstract: Acetaminophen (APAP) is a drug used to treat headaches and fever symptoms, Its metabolites deplete glutathione (GSH) in the liver and cause oxidative stress. Taking large amounts of APAP in a short period of time can lead to liver failure. In this study, yellow-emissive carbon dots (D-CDs) with strong antioxidant ability and good biocompatibility were synthesized by one-step hydrothermal method using catechol (CAT) and 2, 5-dihydroxyterephthalic acid (DHTA) as precursors. In the APAP-induced zebrafish liver injury model, in vivo imaging showed that D-CDs could be effectively enriched in the zebrafish liver, increase the superoxide dismutase (SOD) activity and glutathione (GSH) content, and reduce the level of malondialdehyde (MDA), which finally effectively improve APAP-induced oxidative stress injury in zebrafish.

Key words: Carbon dots, Antioxidant, Acetaminophen, Liver injury, Zebrafish

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LI Yan, CAI Hao, BI Hong. Antioxidative Carbon Dots Improving Acute Liver Injury Induced by Acetaminophen[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20240130.

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Antioxidative Carbon Dots Improving Acute Liver Injury Induced by Acetaminophen

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