Red-Emissive Mitochondria-Targeting Iron-Doped Carbon Dots for Tumor Therapy via Peroxidase-Mimicking Activity-Induced Ferroptosis

doi:10.7503/cjcu20250094

Chem. J. Chinese Universities

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Red-Emissive Mitochondria-Targeting Iron-Doped Carbon Dots for Tumor Therapy via Peroxidase-Mimicking Activity-Induced Ferroptosis

XUE Xiaokuang^1,2, LI Jian^1,2, LIANG Huanyi^1,2, WANG Yiying³, GE Jiechao^1,2

1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences 2. School of Future Technology, University of Chinese Academy of Sciences 3. Tianjin People's Hospital,

Received:2025-04-02 Revised:2025-04-11 Online First:2025-04-28 Published:2025-04-28
Contact: Jiechao Ge

1. ESM to 20250094.pdf(816KB)

Abstract

Abstract: In this study, iron-doped carbon dots (Fe-CDs) with strong peroxidase-mimicking activity were synthesized for tumor-specific therapy. Their intrinsic red fluorescence enabled high-contrast cellular imaging, revealing preferential mitochondrial accumulation. In the acidic, hydrogen peroxide (H2O2)-rich tumor microenvironment, Fe-CDs catalyzed hydroxyl radical (·OH) generation, inducing oxidative stress and lipid peroxidation, ultimately triggering ferroptosis. In vitro and in vivo studies demonstrated potent tumor inhibition. Furthermore, Fe-CDs exhibited excellent biocompatibility with no significant systemic toxicity. By integrating fluorescence imaging and catalytic therapy, this study presents a promising nanoplatform for tumor treatment and ferroptosis research.

Key words: Carbon Dots, Nanozyme; Mitochondria-Targeting, Ferroptosis, Tumor Therapy

CLC Number:

O636

TrendMD:

XUE Xiaokuang, LI Jian, LIANG Huanyi, WANG Yiying, GE Jiechao. Red-Emissive Mitochondria-Targeting Iron-Doped Carbon Dots for Tumor Therapy via Peroxidase-Mimicking Activity-Induced Ferroptosis[J]. Chem. J. Chinese Universities, doi: 10.7503/cjcu20250094.

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Red-Emissive Mitochondria-Targeting Iron-Doped Carbon Dots for Tumor Therapy via Peroxidase-Mimicking Activity-Induced Ferroptosis

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