Melanin-based Targeted Nanodrugs for Photothermal Therapy of Breast Cancer

doi:10.7503/cjcu20230044

Abstract

Abstract:

To improve the targeting effect of small-sized melanin nanoparticles（MNP） at tumor sites， a hydroxyapatite hybrid mesoporous silica（MSN/HAP）， which is degradable in tumor micro-acidic environment， was designed and synthesized for loading， and a novel highly targeted nanodrug（MAN/HAP-MNP-RGD） was constructed in combination with RGD-directed peptide for multimodal imaging and photothermal therapy of mouse breast cancer. The physicochemical properties of nanoparticles， cellular and invivo experiments were examined and the results showed that the final particle size was approximately 60 nm， the loading of MNP was 37.7%， the nanoparticles showed good degradability in a slightly acidic environment， and the photothermal conversion efficiency of the nanoparticles was 40.29%. In addition， the results of photoacoustic imaging and magnetic resonance imaging showed that the nano- particles showed higher accumulation and longer retention time at the tumor site. Finally， the in vivo experiments demonstrated that MAN/HAP-MNP-RGD has the best therapeutic effect and high biosafety， showing potential applications.

Key words: Hydroxyapatite hybrid mesoporous silica, Melanin nanoparticle, Photoacoustic imaging, Magnetic resonance imaging, Photothermal therapy

CLC Number:

O613.72

TrendMD:

SUN Jinghua, GUO Chunyan, DONG Jie, ZHANG Ruiping. Melanin-based Targeted Nanodrugs for Photothermal Therapy of Breast Cancer[J]. Chem. J. Chinese Universities, 2023, 44(8): 20230044.

Figures/Tables 14

References 25

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