Fabrication of HCPT-Layered Double Hydroxide Nanohybrids via Co-assembly Method and Its Characterization

doi:10.7503/cjcu20150589

Chem. J. Chinese Universities ›› 2016, Vol. 37 ›› Issue (3): 567.doi: 10.7503/cjcu20150589

• Physical Chemistry • Previous Articles Next Articles

Fabrication of HCPT-Layered Double Hydroxide Nanohybrids via Co-assembly Method and Its Characterization

PANG Xiujiang¹, LIU Yuan¹, CHEN Li², QUAN Zhenlan¹

1. State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;
2. Key Laboratory of Rubber-plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plastics, College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Received:2015-07-27 Revised:2016-01-13 Online:2016-03-10 Published:2016-01-13
Supported by:
Supported by the Natural Science Foundation of Shandong Province, China(No.ZR2014BL005) and the Doctoral Fund of Qingdao University of Science and Technology of China(No.0022610).

Abstract

Abstract:

Hydroxyl camptothecin-layered double hydroxides(HCPT-LDH) nanohybrids were prepared by co-assembling between HCPT and Zn₂Al-NO₃ LDH nanosheets prepared using microchannel reactor, which indicated the obtained nanosheets could be used to fabricate LDH based drug delivery and controlled release system. After being treated with acetic acid, inactive carboxylate form HCPT transformed into bioactive lactone form HCPT. It is important for preparing high bioactive HCPT-LDH nanohybrids. The co-assembly method showed various remarkable advantages, such as simple procedure, short reation time, mild condition, high drug loading and good dispersity. Additionally, drug loading can be easily controlled by adjusting raw material ratios. HCPT molecules arrays aslant in double layers along longitudinal axis in the gallery of LDH. The nanohybrids showed well controlled release property and in vitro drug release kinetics from the nanohybrids could be fitted with the pseudo-second-order kinetic model. The diffusion of HCPT through the LDH particles played an important role in the control of the drug release.

Key words: Hydroxyl camptothecin, Layered double hydroxides, Co-assemble, Nanohybrids

CLC Number:

O641.1

TrendMD:

PANG Xiujiang, LIU Yuan, CHEN Li, QUAN Zhenlan. Fabrication of HCPT-Layered Double Hydroxide Nanohybrids via Co-assembly Method and Its Characterization[J]. Chem. J. Chinese Universities, 2016, 37(3): 567.

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Fabrication of HCPT-Layered Double Hydroxide Nanohybrids via Co-assembly Method and Its Characterization

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