Synthesis and Characterization of 10-Hydroxyl Camptothecin-Sebacate-LDH Nanohybrid

doi:10.7503/cjcu20120878

Abstract

Abstract:

The nanohybrid of 10-hydroxyl camptothecin(HCPT)-sebacate(SC)-intercalated layered double hydroxide(LDH), HCPT-SC-LDH, was prepared by a secondary intercalation method. First, the nanohybrid of SC intercalated Mg₂Al-NO₃ LDH was prepared by a co-precipitation method; second, HCPT was intercalated into the LDH's gallery in ethanol medium. According to the gallery height of the SC-LDH sample and the size of SC molecule, a probably morphology of the SC molecules in the gallery of LDH was suggested that the SC molecules arranged as a bilayer structure in which two carboxylate groups of SC molecule combined onto one LDH layer surface. And HCPT was intercalated into the LDH's gallery via hydrophobic interaction. The encapsulated HCPT could keep biologically active lactone structure, and the nanohybrid could improve the HCPT solubility. Moreover, the obtained HCPT-SC-LDH nanocomposites showed obvious controlled release and the release in vitro of HCPT could be fitted with the pseudo-second-order model.

Key words: 10-Hydroxyl camptothecin, Layered double hydroxide(LDH), Sebacate, Nanohybrid, Controlled release

CLC Number:

O641.1

TrendMD:

MA Xiu-Ming, PANG Xiu-Jiang, QUAN Zhen-Lan, HOU Wan-Guo. Synthesis and Characterization of 10-Hydroxyl Camptothecin-Sebacate-LDH Nanohybrid[J]. Chem. J. Chinese Universities, 2013, 34(4): 913.

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