Synthesis and Characterization of PLGA-PEG-PLGA Triblock Copolymer with Side Propargyl Groups

doi:10.7503/cjcu20120624

Abstract

Abstract:

In order to introduce the propargyl groups to the side chains of biodegradable polyester which avai-lable for the attachment of functionality using "click" chemistry, the propargyl glycolide(PG) monomer was synthesized and characterized by FTIR and ¹³C NMR. Then, a series of PLGA-PEG-PLGA tri-block copolymers with side propargyl groups was prepared by bulk ring-opening copolymerization of L-lactide and propargyl glycolide using 1,4-dimethylaminopyridine(DMAP) as a catalyst and polyethylene glycol(PEG) as a cointiator with different feed ratios(n_PEG:n_PG:n_L_-LA). The structure and properties of the PLGA-PEG-PLGA tri-block copolymers with side propargyl groups were studied by FTIR, ¹H NMR and gel permeation chromatography.

Key words: Biodegradable polyester, Modification, Click chemistry, Propargyl glycolide, PLGA-PEG-PLGA triblock copolymer

CLC Number:

O633.1

TrendMD:

XU Chong-En, YANG Jing, LUO Bing-Hong, LI Jian-Hua, XU Wan, ZHOU Chang-Ren. Synthesis and Characterization of PLGA-PEG-PLGA Triblock Copolymer with Side Propargyl Groups[J]. Chem. J. Chinese Universities, 2012, 33(10): 2138.

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Synthesis and Characterization of PLGA-PEG-PLGA Triblock Copolymer with Side Propargyl Groups

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