Direct Determination of Lead and Cadmium in Distilled Spirits by Inductively Coupled Plasma Mass Spectrometry Coupled with Chip-based Microflow Injection System

doi:10.3969/j.issn.0251-0790.2012.09.014

Abstract

Abstract:

A microfluidic chip for introducing variable-volume sample was fabricated. Combined with the 8-way multifunctional valve used in flow injection analysis, the introduction of sub-microlitre sample in inductively coupled plasma mass spectrometry (ICP-MS) was realized. 52% ethanol was used to simulate the distilled spirit. The effects of the volume of the 52% ethanol introduced into ICP-MS on ICP stability and the spectral interference from the spirit matrix were studied. The relationship between the sampling volume and sensitivity was evaluated. The carrier flow rate was optimized. The experimental results showed that neither alteration of plasma stability nor carbon deposition was observed when the sampling volume of 52% ethanol reduced down to 0.8 μL. Further reducing the sampling volume to 0.3 μL, the interference from carbon was eliminated. Based on these observations, a microflow injection method for the determination of lead and cadmium in distilled spirits by ICP-MS via external aqueous calibration was developed. The sample throughput was 45 h^-1 with the detection limits of 12 and 42 ng/L for Pb and Cd, respectively. The contents of Cd and Pb in six distilled spirits were measured. The results agreed well with those determined by ICP-MS with the conventional sampling system after microwave assisted digestion.

Key words: Microfluidic chip, Sub-microlitre sampling, Inductively coupled plasma mass spectrometry(ICP-MS), Distilled spirit, Direct analysis

CLC Number:

O657

TrendMD:

HAO Li, CHENG He-Yong, LIU Jin-Hua, YIN Xue-Feng. Direct Determination of Lead and Cadmium in Distilled Spirits by Inductively Coupled Plasma Mass Spectrometry Coupled with Chip-based Microflow Injection System[J]. Chem. J. Chinese Universities, 2012, 33(09): 1957.

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