高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (8): 1259.

• 研究简报 • 上一篇    下一篇

二茂钛二甘氨酸盐酸盐与DNA作用机理的研究

张志刚1, 杨频2   

  1. 1. 南京大学化学系配位化学国家重点实验室, 南京 210093;
    2. 山西大学分子科学研究所, 太原 030006
  • 收稿日期:1996-07-23 出版日期:1997-08-24 发布日期:1997-08-24
  • 通讯作者: 杨频.
  • 作者简介:张志刚, 男, 28岁, 博士研究生, 讲师.
  • 基金资助:

    国家自然科学基金;配位化学国家重点实验室基金;山西省青年科学基金

A Study of the Interaction Between Titanocene Glycine Complex and DNA

ZHANG Zhi-Gang1, YANG Pin2   

  1. 1. Institute of Molecular Science, Nanjing University, Nanjing, 210093;
    2. Dept.of Chem., State Key Lab. of Coordination Chem., Shanxi University, Taiyuan, 030006
  • Received:1996-07-23 Online:1997-08-24 Published:1997-08-24

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被引次数

15

关键词: 二茂钛二甘氨酸盐酸盐, 抗肿瘤, DNA

Abstract: The interaction between titanocene glycine complex and DNAhas been investigat-ed by UV-Vis spectra and fluorescence probe method. The results suggest that the complex forms an irreversible adduct with DNAin molar ratio 1:1, and induces the comformation changes of DNAat high ratio of the complex to DNA,leading to the disruption of DNAdu-plexical structure.

Key words: Titanocene glycine complex, Antitumor, DNA

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