高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (9): 1637.

• 研究论文 • 上一篇    下一篇

3-芳基-1-二茂铁基-2-(1H-1,2,4-三唑-1-基)-2-丙烯酮类衍生物的选择性还原、产物结构表征及其生物活性研究

金钟, 刘伟, 霍爱红, 刘建兵, 方建新   

  1. 南开大学元素有机化学国家重点实验室, 天津300071
  • 收稿日期:2004-09-13 出版日期:2005-09-10 发布日期:2005-09-10
  • 基金资助:

    国家自然科学基金(批准号:29872022,20172030);高等学校博士学科点专项科研基金(批准号:9805520)资助.

Selective Reduction, Characterization and Biological Activity of 3-Aryl-1-ferrocynyl-2-(1H-1,2,4-triazol-1-yl)-2-propen-1-one Derivatives

JIN Zhong, LIU Wei, HUO Ai-Hong, LIU Jian-Bing, FANG Jian-Xin   

  1. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:2004-09-13 Online:2005-09-10 Published:2005-09-10

PDF (PC)

摘要： 以烯效唑和苄氯三唑醇为目标先导化合物,通过在分子中引入二茂铁基团,设计合成了两类20个新颖的含二茂铁基取代的三唑醇类衍生物,并对α,β-不饱和二茂铁基酮的选择性还原条件进行了讨论.所合成化合物的结构经元素分析、1HNMR谱和X射线晶体衍射分析得以确证.生物活性测试表明,部分化合物具有一定的植物生长调节活性.

关键词: 1H-1, 2, 4-三唑, 二茂铁, 还原, 杀菌活性, 植物生长调节活性

Abstract: 3-Aryl-1-ferrocenyl-2-(1H-1,2,4-triazole)-1-yl-2-propen-1-one derivatives were prepared from ferrocene and reduced to related saturated and unsaturated alcohol derivatives under the selective conditions, respectively. In addition, selective reduction of α,β-unsaturated ferrocenyl ketone was also discussed. The structures of the title compounds were characterized by elemental analysis,1H NMR and X-ray diffraction analysis. It was shown that ferrocene, as an organometallic compound, was introduced into bioactive triazole compounds in search of potent bioactive substances. Bioassay displayed that some of the title compounds possess fungicidal activity against C. ara and the unsaturated alcohol derivatives showed higher plant-growth regulatory activity than saturated ones.

Key words: 1H-1,2,4-Triazole, Ferrocene, Reduction, Fungicidal activity, Plant-growth regulatory activity

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