高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (5): 988.

• 研究简报 • 上一篇    

聚肽接枝共聚物的自组装行为研究

陈涛, 汤冬梅, 林嘉平, 朱国全, 章苏宁, 田晓慧   

  1. 华东理工大学材料科学与工程学院超细材料制备与应用教育部重点实验室, 上海200237
  • 收稿日期:2004-05-24 出版日期:2005-05-10 发布日期:2005-05-10
  • 通讯作者: 林嘉平(1964年出生),男,教授,博士生导师,主要从事高分子物理与化学研究.E-mail:jplinlab@online.sh.cn E-mail:jplinlab@online.sh.cn
  • 基金资助:

    国家自然科学基金(批准号:50273011);教育部博士学科点基金(批准号:20010251008);上海市科学技术委员会纳米专项基金(批准号:0352nm109)资助.

Self-assembly Behavior of Polypeptide Graft Copolymer

CHEN Tao, TANG Dong-Mei, LIN Jia-Ping, ZHU Guo-Quan, ZHANG Sun-Ning, TIAN Xiao-Hui   

  1. School of Materials Science and Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
  • Received:2004-05-24 Online:2005-05-10 Published:2005-05-10

PDF (PC)

被引次数

3

关键词: 聚肽, 接枝共聚物, 自组装, 胶束, 荧光

Abstract: Polymeric micelles of poly(γ-benzyl L-glutamate)(PBLG)-poly(ethylene oxide)(PEO) graft copolymer were prepared by the dialysis method in deionized water. Fluorescence spectroscopy, nuclear magnetic resonance(NMR) and transmission electron microscope(TEM) were used for the investigation of the self-assembly of PBLG-PEO graft copolymer. Fluorescence spectrosco0y measurements suggest that PBLG-PEO graft copolymer associates to form polymeric micelles in water. 1H NMR measurements further prove that in aqueous medium PBLG-PEO graft copolymer could assemble into polymeric micelles with PBLG segments as the hydrophobic inner core and PEO segments as the hydrophilic shell. The results of the TEM observations show that the polymeric micelles of PBLG-PEO graft copolymer are almost spindly shaped, which are different from the morphology of the spherical micelles formed by PBLG-PEO block copolymer. Polymeric micelles formed by polypeptide copolymer have potential application as drug carrier in controlled-release delivery system.

Key words: Polypeptide, Graft copolymer, Self-assembly, Micelle, Fluorescence

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