微乳液电动色谱测定油-水分配系数的改进方法研究

高等学校化学学报

微乳液电动色谱测定油-水分配系数的改进方法研究

蒋雪梅^{1, 2}, 魏为力¹, 姜军坡¹, 石开云², 穆小静¹, 陈志涛², 夏之宁^{1, 2}

1. 重庆大学化学化工学院药学系,
2. 生物力学与组织工程教育部重点实验室, 重庆 400044

收稿日期:2005-12-15 修回日期:1900-01-01 出版日期:2006-08-10 发布日期:2006-08-10
通讯作者: 夏之宁

Measurement of Oil-Water Partition Coefficients by Improved Microemulsion Electrokinetic Chromatography

JIANG Xue-Mei^1,2, WEI Wei-Li¹, JIANG Jun-Po¹, SHI Kai-Yun², MU Xiao-Jing¹, CHEN Zhi-Tao², XIA Zhi-Ning^1,2

1. Department of Pharmaceutics, Institute of Chemistry and Chemical Engineering,
2. Key Laboratory for Biomechanics and Tissue Engineering, Ministry of Education, Chongqing University, Chongqinq 400044, China

Received:2005-12-15 Revised:1900-01-01 Online:2006-08-10 Published:2006-08-10
Contact: XIA Zhi-Ning

摘要/Abstract

摘要： 通过考察微乳液电动色谱(MEEKC)中化合物浓度和高电场对其迁移行为的影响, 探讨了化合物分配于微乳后改变微乳内相性质的原因, 以及电泳高电场致使微乳液性质变化的机理. 在此基础上建立了一种测定化合物油-水分配系数的改进型MEEKC方法. 将此改进方法应用于烷基苯化合物之油-水分配系数的测定, 其测定值与文献参考值平均相差0.07个对数单位, 准确度较现行MEEKC方法有了明显提高.

关键词: MEEKC, 改进方法, 油-水分配系数, 高电场

Abstract: Microemulsion electrokinetic chromatography(MEEKC) was used as a powerful method for the indirect measurement of oil-water partition coefficients of organic compounds. Considering the problems of determining oil-water partition coefficients by conventional MEEKC, the concentration of solute and high electric-field having impact on the migration behavior of compound was studied, the reason and mechanism of which were also studied. Moreover, an improved method of MEEKC(I-MEEKC) that can be used to solve the problems found was developed. Applying this improved method to determining oil-water partition coefficients for compounds, such as alkyl-benzene: benzene, toluene and ethyl benzene, good result was obtained: the average error between oil-water partition coefficients estimated by using improved MEEKC and literature values published was 0.07 logarithm units. In this work not only a new method was established to measure oil-water partition coefficients with MEEKC, but also the improved MEEKC is developed further and become more reliable and more accurate method for qualitative analysis.

Key words: MEEKC, Improved method, Oil-water partition coefficients, High electric-field

中图分类号:

O657

TrendMD:

蒋雪梅, ,魏为力,姜军坡,石开云,穆小静,陈志涛,夏之宁, . 微乳液电动色谱测定油-水分配系数的改进方法研究. 高等学校化学学报, doi: .

JIANG Xue-Mei^1,2, WEI Wei-Li¹, JIANG Jun-Po¹, SHI Kai-Yun², MU Xiao-Jing¹, CHEN Zhi-Tao², XIA Zhi-Ning^1,2. Measurement of Oil-Water Partition Coefficients by Improved Microemulsion Electrokinetic Chromatography. Chem. J. Chinese Universities, doi: .

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