关键词: 微流控芯片, 分析化学实验室； 分子水平, 细胞水平, 临床诊断, 药物筛选

Abstract: This article provides an overview of the recent achievements of analysis laboratory on a microfluidic chip and their applications in molecular, cell and organism level based on the works mainly carried out in the authors laboratory. The chip fabrication capabilities have been extended into design and fabricate chips with higher degree of complexity in different materials, quartz, glass, PMMA, PDMS, and hydrogel etc. Various functional units such as sampling, separation, micro pumps/valves, droplet, membrane, SPE, PCR reaction, cell culture, sorting and lysis etc. were prepared and integrated. And these devices with higher degree of complexity and functional units have been demonstrated for a wide range of biomedical applications. Microfluidic devices built for drug metabolites and drug screening in cell and organism level were described in this review.

Key words: Microfluidic chip, Analysis laboratory, Molecular level, Cell level, Clinical diagnostics, Drug screening