高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

嵌段共聚物OSM1-PCLA-PEG-PCLA-OSM1的合成及其pH和温度敏感性

郝堂娜, 乔明曦, 古建春, 李镇, 胡海洋, 赵秀丽, 陈大为   

  1. 沈阳药科大学药学院, 沈阳 110016
  • 收稿日期:2007-12-18 修回日期:1900-01-01 出版日期:2008-10-10 发布日期:2008-10-10
  • 通讯作者: 陈大为

Synthesis and pH and Temperature Sensitive Properties of OSM1-PCLA-PEG-PCLA-OSM1 Block Copolymers

HAO Tang-Na, QIAO Ming-Xi, GU Jian-Chun, LI Zhen, HU Hai-Yang, ZHAO Xiu-Li, CHEN Da-Wei*   

  1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2007-12-18 Revised:1900-01-01 Online:2008-10-10 Published:2008-10-10
  • Contact: CHEN Da-Wei

PDF (PC)

摘要： 采用开环聚合法和自由基聚合法合成了生物可降解嵌段共聚物OSM1-PCLA-PEG-PCLA-OSM1, 并对其进行了结构表征. 采用荧光分光光度计和激光粒度仪对共聚物溶液临界胶束浓度(CMC)和粒径大小及分布进行了考察, 研究了温度和pH对共聚物胶束形成的影响. 相转变过程研究结果表明, 共聚物溶液具有pH和温度双重敏感性. 共聚物溶液在一定温度和pH条件下可发生溶液-凝胶相转变.

关键词: pH敏感, 温度敏感, 生物可降解, 嵌段共聚物, 水凝胶

Abstract: A new kind of biodegradable pH and temperature sensitive block copolymers were synthesized by ring-opening and conventional free radical polymerizations. The chemical structure of OSM1-PCLA-PEG-PCLA-OSM1 block copolymers was characterized via FTIR and 1H NMR. Critical micelle concentration and particle size distribution were studied by fluorospectrophotometer and laser size detector to verify the copolymers micelle formation. The results of sol-gel transition show that the block copolymers solution possesses both pH and temperature sensitive properties. Different block copolymer solutions can form a stable gel obviously at certain temperature. OSM1-PCLA-PEG-PCLA-OSM1 block copolymers could be potential intelligent polymers materials for drug delivery system because of its pH and temperature sensitive properties.

Key words: pH sensitivity, Temperature sensitivity, Biodegradation, Block copolymer, Hydrogels

中图分类号: 

TrendMD: