高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (2): 221-223.

• 研究简报 • 上一篇    

胃癌患者胃液的荧光研究

田珂1, 王今堆1, 戴巾1, 张丽芳1, 马荣久1, 陈晓光1, 丁忠田1, 李铁津1, 刘志广2, 郑扶民2   

  1. 1. 吉林大学;
    2. 白求恩医科大学
  • 收稿日期:1987-07-27 出版日期:1989-02-24 发布日期:1989-02-24
  • 通讯作者: 田珂

Studies on the Fluorescent Substance in Gastric Juice from Patients Suffering from Stomach Carcinoma

Tian Ke1, Wang Jindui1, Dai Jin1, Zhang Lifang1, Ma Rongjiu1, Chen Xiaoguang1, Ding Zhonglian1, Li Tiejin1, Liu Zhiguang2, Zheng Fumin2   

  1. 1. Jilin University, ChangChan;
    2. Bethune Medical University, ChangChuh
  • Received:1987-07-27 Online:1989-02-24 Published:1989-02-24

摘要: 利用外加荧光物质在肿瘤部位的特征吸附,或通过恶性肿瘤的自体荧光进行临床诊断及治疗均有报道,但对外加或自体荧光物质的认识大都集中于卟啉类分子。我们在利用胃液对胃癌特征荧光物质的研究中,首次提出了黄素蛋白类为胃癌胃液的特征荧光物质及存在形式,为胃癌的临床诊断和治疗及癌变机理的阐明提供了新的依据。

关键词: 胃液, 黄素, 荧光

Abstract: This paper reports a characteristic fluorescent substance in gastric juice from the patients suffering from stomach carcinoma and its probable existance form. The systematic separation for the gastric juice with stomach carcinoma was carried out by biochemical methods. The comparisons of the fluorescence spectra and excited spectra of the gastric juice with stomach carcinoma with that of the aqueous solution of riboflavin and the experiments based on the properties of riboflavins make us come to the conclusion that the characteristic fluorescent substance in the gastric juice from the patients of stomach carcinoma is riboflavin-binding protein and probably exists in phospholipid membrane.

Key words: Gastric juice, Riboflavin, Fluorescence