高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (11): 1465.

• 论文 • 上一篇    下一篇

(+)-1R,3R,5S-1,8,8-三甲基-3-硫代-3-(4-甲基苯氧基)-2,4,3-二氮磷杂二环[3,2,1]辛烷的合成和分子绝对构型

刘小兰1, 缪方明1, 刘立建2, 陈茹玉2   

  1. 1. 天津师范大学化合物, 天津, 300074;
    2. 南开大学元素有机化学研究所
  • 收稿日期:1990-05-14 出版日期:1991-11-24 发布日期:1991-11-24
  • 通讯作者: 缪方明

Synthesis, Crystal Structure and Absolute Configuration of (+)-1R, 3R,5S-1,8,8-Trimethyl-3-Thio-3-(4-Methyl-Phenyloxo)-2,4,3-Diaza-Phosphabicyclo[3,2,1] Octane

Liu Xiao-Ian1, Miao Fang-ming1, Liu Li-jian2, Chen Ru-yu2   

  1. 1. Department of Chemistry, Tianjin Normal University, Tianjin, 300074;
    2. Institute of Elemento-Organic Chemistry, Nankai University
  • Received:1990-05-14 Online:1991-11-24 Published:1991-11-24

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摘要： 合成的标题化合物用X射线衍射方法确定其分子的绝对构型,晶体空间群为P212121,晶胞参数:a=0.8365(3)、b=0.8625(3)、c=2.3513(2)nm,Z=4.结构分析表明,分子骨架中存在3个环结构,即含磷、氮原子的船式七元环、椅式六元环以及由碳原子组成的信封式五元环。P-S键为e键,P-O键为a键。

关键词: 二氮磷杂二环[3, 2, 1]辛烷, 合成, 绝对构型

Abstract: The title compound was synthesized and its crystal and molecular structure was determined by X-ray diffraction analysis with CuKa radiation. The crystal data are as follows; Or-thorhombic system, space group P212121,a=0. 8365(3) nm, b=0. 8625(3) nm, c=2. 3512(2) nm, Z=4. The result of structure analysis shows there are three-membered ring structures in the molecular skeleton, the seven-membered ring is in a boat form and six-membered ring in a chair form including P(1) atom in the two rings, and the five-membered ring composed of carbon atoms is in an envelop form. In the molecule, S(1) is in an equatorial and O(1) in an axial position.Based on the appreciable anomalous scattering effect of Pand Satoms to the CuKa radiation, the absolute configuration of the molecule was established.

Key words: Diazaphosphabicyclo [3,2,1] octane, Synthesis, Absolute configuration

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