高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (5): 1065.doi: 10.7503/cjcu20180764

• 高分子化学 • 上一篇    下一篇

pH响应性树枝状聚合物-金纳米粒子复合药物载体的制备

朱钦富, 胡可珍, 李小杰(), 陈明清   

  1. 江南大学化学与材料工程学院, 合成与生物胶体教育部重点实验室, 无锡 214122
  • 收稿日期:2018-11-14 出版日期:2019-05-06 发布日期:2019-04-18
  • 作者简介:

    联系人简介: 李小杰, 男, 博士, 副教授, 主要从事疾病诊断与治疗纳米药物方面的研究. E-mail: xjli@jiangnan.edu.cn

  • 基金资助:
    国家自然科学基金(批准号: 21504032)和中央高校基本科研业务费专项资金(批准号: JUSRP115A07)资助.

Preparation of Dendrimer-gold Nanoparticle Composites for pH Responsive Drug Delivery

ZHU Qinfu, HU Kezhen, LI Xiaojie*(), CHEN Mingqing   

  1. Key Laboratory of Synthetic and Biological Colloid of the Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 2141221, China
  • Received:2018-11-14 Online:2019-05-06 Published:2019-04-18
  • Contact: LI Xiaojie E-mail:xjli@jiangnan.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No.21504032) and the Fundamental Research Funds for the Central Universities, China(No.JUSRP115A07)

摘要:

以表面接枝聚乙二醇链的聚酰胺胺树枝状聚合物(PEG-PAMAM)为纳米载体, 在其内部空腔包覆金纳米粒子, 在金纳米粒子表面连接硫辛酸改性的阿霉素(LA-DOX), 从而间接实现了抗癌药物在PEG-PAMAM内的高效负载. 同时, LA-DOX中的酰腙键提供pH响应性, 实现了药物的pH响应性释放. 紫外-可见(UV-Vis)光谱表明, 包覆金纳米粒子的PEG-PAMAM纳米载体对LA-DOX的负载能力显著增强. 体外细胞实验表明, 负载LA-DOX的树枝状聚合物-金纳米粒子复合药物载体具有较强的抗肿瘤能力.

关键词: 树枝状聚合物, 金纳米粒子, pH响应性, 纳米药物

Abstract:

Dendrimer-gold nanoparticle composites were prepared based on poly(ethylene glycol) modified dendrimer(PEG-PAMAM). Gold nanoparticles internal provided an efficient platform for lipoic acid functionalized DoxorubicinLA-DOX linking, leading to the high loading efficiency of anticancer drugs DOX. Meanwhile the hydrazine linker in LA-DOX realized pH sensitive release for nanocarrier. Verified by UV-Vis spectra, the loading efficiency of LA-DOX in dendrimer-gold nanoparticle nanocomposite was improved. Cell Experiment indicated excellent cytotoxicity of dendrimer-gold nanoparticle composite against Hela cells.

Key words: Dendrimer, Gold nanoparticles, pH sensitive, Nanomedicine

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