高等学校化学学报 ›› 2011, Vol. 32 ›› Issue (8): 1750.

• 研究论文 • 上一篇    下一篇

新型邻甲酰胺基间苯二甲酰胺类化合物的设计合成及生物活性

闫涛, 于观平, 熊丽霞, 于淑晶, 王素华, 李正名   

  1. 南开大学元素有机化学国家重点实验室, 元素有机化学研究所, 天津 300071
  • 收稿日期:2010-10-08 修回日期:2010-12-09 出版日期:2011-08-10 发布日期:2011-07-19
  • 通讯作者: 李正名 E-mail:nkzml@vip.163. com
  • 基金资助:

    国家“九七三”计划项目(批准号:  2010CB126106)和国家自然科学基金(批准号:  20872069)资助.

Design, Synthesis and Biological Activities of Novel Anthranilic Isophthaloyl Amide

YAN Tao, YU Guan-Ping, XIONG Li-Xia, YU Shu-Jing, WANG Su-Hua, LI Zheng-Ming*   

  1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:2010-10-08 Revised:2010-12-09 Online:2011-08-10 Published:2011-07-19
  • Contact: LI Zheng-Ming E-mail:nkzml@vip.163. com
  • Supported by:

    国家“九七三”计划项目(批准号:  2010CB126106)和国家自然科学基金(批准号:  20872069)资助.

摘要: 氯虫酰胺是一种作用于鱼尼丁受体的新型杀虫剂,具有高效、低毒、广谱的杀虫活性,成为当今农用化学品领域研究的热点。以氯虫酰胺的结构为基础,设计合成了一系列未见文献报道的邻甲酰胺基间苯二甲酰胺类化合物,所有化合物均通过核磁共振氢谱和高分辨质谱表征确定.初步的生物活性测试结果表明,在浓度为200 mg?L-1时,化合物8d杀粘虫活性可达60%;抑菌活性:在浓度为50 mg?L-1时,化合物8d对苹果轮纹病菌的抑菌率为41.7%;化合物8a对小麦赤霉菌的抑菌率为41.2%。

关键词: 氯虫酰胺; , 邻甲酰胺基间苯二甲酰胺; , 杀虫活性; , 抑菌活性

Abstract: Chlorantraniliprole has been widely studied in the agrochemical field, which is significant in the field of crop protection, particularly important in light of the ability of insects to rapidly developresistance and the need for safe and effective pesticides that act at Ryanodine receptor. A series of novel anthranilic isophthaloyl amides developed from the structure of Chlorantraniliprole was designed and synthesized. Their structures were characterized by 1HNMR and HRMS. The preliminary results of biological activity experiment showed that compound 8d exhibited 60% insecticidal activity against Mythimna separata Walker at 200 mg?L-1; compound 8d exhibited 41.7% fungicidal activity against Physalospora piricola and compound 8a exhibited 41.2% fungicidal activityagainst Gibberella sanbinetti at 50 mg?L-1.

Key words: Chlorantraniliprole; , Anthranilic isophthaloyl amide; , Insecticidal activity; , Fungicidal activity

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