高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (4): 632-638.doi: 10.7503/cjcu20180733

• 无机化学 • 上一篇    下一篇

稀土氮杂环配合物的合成、 结构及抑菌活性

李冰1, 王学敏1, 白凤英1(), 刘淑清2()   

  1. 1. 辽宁师范大学化学化工学院, 大连 116029
    2. 大连医科大学基础医学院生物化学教研室, 大连 116044
  • 收稿日期:2018-10-29 出版日期:2019-04-03 发布日期:2019-04-10
  • 作者简介:

    联系人简介: 白凤英, 女, 博士, 副教授, 主要从事稀土功能材料方面的研究. E-mail: baifengying2003@163.com;刘淑清, 女, 博士, 教授, 主要从事肿瘤生物学方面的研究. E-mail: Lsqsmz@163.com

  • 基金资助:
    国家自然科学基金(批准号: 21571091)和辽宁省科学事业公益研究基金(批准号: 20170055)资助.

Synthesises, Structures and Antibacterial Activities of a Series of Rare Earth Nitrogen Heterocyclic Complexes

LI Bing1, WANG Xuemin1, BAI Fengying1,*(), LIU Shuqing2,*()   

  1. 1. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China
    2. Department of Biochemistry, School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China
  • Received:2018-10-29 Online:2019-04-03 Published:2019-04-10
  • Contact: BAI Fengying,LIU Shuqing E-mail:baifengying2003@163.com;Lsqsmz@163.com
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No.21571091) and the Public Welfare Research Foundation of Liaoning Province, China(No.20170055).

摘要:

采用溶液合成法, 在室温下合成了一系列稀土配合[Ln(IAA)2(phen)2]·(NO3)[Ln=Ce(1), Gd(2), Tb(3), Dy(4), Ho(5), HIAA=吲哚乙酸, phen=1,10-菲咯啉], 并通过元素分析、 红外光谱、 热重分析、 X射线单晶衍射、 X射线粉末衍射等方法对配合物进行了表征. 结果表明, 配合物15具有相同的结构, 对配合物2的单晶结构分析表明, 配合物2为超分子网络结构, 通过分子间氢键形成2D网络, 中心金属Gd(Ⅲ)为九配位, 具有单帽四方反棱柱几何构型. 此外, 对该系列配合物进行了抑菌活性的研究, 得到了抑菌活性与配合物组成的构效关系.

关键词: 稀土配合物, 吲哚乙酸, 1,10-菲咯啉, 晶体结构, 抑菌活性

Abstract:

A series of rare earth metal complexes, [Ln(IAA)2(phen)2]·(NO3)[Ln=Ce(1), Gd(2), Tb(3), Dy(4), Ho(5). HIAA=indole acetic acid, phen=1,10-phenanthroline], was synthesized via the solution synthesis method at room temperature. The structures of the complexes were characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, X-ray single crystal diffraction and powder polycrystalline diffraction. Structural analyses show that complex 2 has a supramolecular network structure and its 2D network structure is formed through intermolecular hydrogen bonds. The central metal Gd(Ⅲ) is nine-coordinated with a single-capped quadrilateral inverse prism geometry. In addition, the antibacterial activity of the five complexes was studied, and the structure-activity relationship between antibacterial activity and composition of complexes was analysized.

Key words: Rare earth complex, Indole acetic acid, 1,10-Phenanthroline, Crystal structure, Antibacterial activity

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