关键词: 1-(4-取代苯基)-4-苯基-5-水杨醛亚胺-1,2,3-三唑, 1-(4-取代苯基)-4-苯基-5-(2-羟基苄基)氨基-1,2,3-三唑, 抗菌药物, 抑菌活性

Abstract: In order to search  for novel and high active fungicides with triazole moiety, a series of novel 1-(4-substituted phenyl)-4-phenyl-5-substituted-1,2,3-triazole derivatives was designed and synthesized by means of combining segments o-hydroxy phenyl and 1,2,3-triazole. Firstly, 1-(4-substitutedphenyl)-4-phenyl-5-(2-iminomethyl phenol)-1,2,3-triazole derivatives(3a—3e) were designed and synthesized through diazotization, azidozation, ring-closure reaction and condensation, and then were reduced by sodium borohydride to synthesize 1-(4-substituted phenyl)-4-phenyl-5-(2-hydroxy benzyl)amino-1,2,3-triazole(4a—4e). The structures of final products were determined by 1H NMR, elemental analysis and IR. The results of antibacterial activity showed that the title compounds except 3e and  4e had over 95% inhibitory rate against Monilia albican, and over 85% inhibitory rate against Escherichia coliis at  a mass concentration of  0.1 mg/L. The results suggest that the title compounds might be potential candidates for antibacterial drugs.

Key words: 1-(4-Substituted phenyl)-4-phenyl-5-(2-iminomethyl phenol)-1,2,3-triazole, 1-(4-Substituted phenyl)-4-phenyl-5-(2-hydroxybenzyl)amino-1,2,3-triazole, Antibacterial drug, Antibacterial activity