高等学校化学学报

高等学校化学学报 ›› 2009, Vol. 30 ›› Issue (6): 1075.

• 研究论文 • 上一篇    下一篇

同时含α-[Mo8O26]4-和β-[Mo8O26]4-的新型超分子化合物的合成、表征及其抗肿瘤活性

赵文秀1, 李妍1, 董顺福1, 彭军2   

  1. 1. 吉林医药学院药学院, 吉林 132013;
    2. 东北师范大学化学学院, 长春 130024
  • 收稿日期:2008-10-09 出版日期:2009-06-10 发布日期:2009-06-10
  • 通讯作者: 彭军, 女, 教授, 博士生导师, 主要从事多酸化学研究. E-mail: jpeng@nenu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20671016)和吉林省教育厅“十一五”自然科学项目(批准号: 2006124)资助.

Synthesis, Characterization and Anti-tumor Activity of a Novel Supramolecular Compound with α-[Mo8O26]4- and β-[Mo8O26]4-

ZHAO Wen-Xiu1, LI Yan1, DONG Shun-Fu1, PENG Jun2*   

  1. 1. Faculty of Pharmacy, Jilin Medical College, Jilin 132013, China;
    2. College of Chemistry, Northeast Normal University, Changchun 130024, China
  • Received:2008-10-09 Online:2009-06-10 Published:2009-06-10
  • Contact: PENG Jun, E-mail: jpeng@nenu.edu.cn
  • Supported by:

    国家自然科学基金(批准号: 20671016)和吉林省教育厅“十一五”自然科学项目(批准号: 2006124)资助.

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摘要：

以(NH4)2[Mo4O13]·2H2O, NiCl2·6H2O和2-(1H-吡唑-3-基)吡啶为原料, 通过水热方法合成了一个新颖的[Ni(C8N3H7)3]4[Mo8O26]2·7H2O超分子化合物. 采用元素分析、红外光谱和单晶X射线衍射法表征了该无机-有机杂化配合物的结构. 晶体解析表明, 该化合物同时含有α-[Mo8O26]4-和β-[Mo8O26]4-, 在[Ni(C8N3H7)3]2+阳离子和[Mo8O26]4-阴离子之间通过氢键作用结合, 在[Ni(C8N3H7)3]2+阳离子之间通过芳香环的π-π堆积作用连接, 两种[Mo8O26]4-阴离子作为客体共存于一个具有三维蜂窝状的超分子结构中. 同时研究了该化合物对人卵巢癌细胞SK-OV-3、肺癌细胞A549、宫颈癌细胞Hela和乳腺癌细胞MCF-7等细胞的体外抗肿瘤活性. 结果表明, 该化合物对3种不同来源的肿瘤细胞均有一定的增殖抑制作用, 其中对MCF-7细胞的IC50值为6.48 μmol/L, 具有进一步研究的价值.

关键词: 水热合成, 钼-氧簇合物, 抗肿瘤活性, 体外实验

Abstract:

A novel supramolecular compound with the formula [Ni(C8N3H7)3]4[Mo8O26]2·7H2O was synthesized by the hydrothermal reaction of (NH4)2[Mo4O13]·2H2O, NiCl2·6H2O and [2-(1H-pyrazol-3-yl)-pyridine].The inorganic-organic hybrid material was characterized by IR spectroscopy, elemental analysis and single-crystal X-ray diffraction. The results of X-ray diffraction indicate that the title complex contains both α- and β-octamolybdates. Leading to the connection between the [Ni(C8N3H7)3]2+ complex cation and [Mo8O26]4- through hydrogen bonding interactions, and the connection between the complex cation [Ni(C8N3H7)3]2+ groups through π-π stacking interactions between aromatic rings, two kinds of octamolybdate anions as guests were accommodated in a 3D “honeycomb” host supramolecular network. Therefore, in vitro anti-tumor activity of the compound on human ovarian cancer cells SK-OV-3, human lung cancer cells A549, human cervical cancer cells Hela and human breast cancer cells MCF-7 was studied. The results show that the compound has a certain degree of growth inhibition to three different sources of tumor cells. In particular, the IC50 value to the MCF-7 cells is 6.48 μmol /L, it shows that the compound has the value for further study.

Key words: Hydrothermal synthesis, Molybdenum-oxygen cluster, Anti-tumor activity, in vitro test

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