高等学校化学学报

高等学校化学学报

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肝靶向甘草次酸修饰的壳聚糖纳米粒子的合成和表征

查瑞涛1,2, 贺晓婷1, 杜田1, 袁直1   

    1. 南开大学高分子化学研究所, 功能高分子材料教育部重点实验室, 天津 300071;
    2. 天津科技大学材料科学与化学工程学院, 天津 300457
  • 收稿日期:2006-12-04 修回日期:1900-01-01 出版日期:2007-06-10 发布日期:2007-06-10
  • 通讯作者: 袁直

Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier

ZHA Rui-Tao1,2, HE Xiao-Ting1, DU Tian1, YUAN Zhi1*   

    1. Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;
    2. College of Material Science and Chemical Engineering, Tianjin University of Science & Technology, Tianjin 300457, China
  • Received:2006-12-04 Revised:1900-01-01 Online:2007-06-10 Published:2007-06-10
  • Contact: YUAN Zhi

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被引次数

24

摘要： 合成了修饰甘草次酸的壳聚糖(GA-CTS), 采用离子交联法制备了GA-CTS纳米粒子. 该材料可能具有肝细胞主动靶向作用, 为进一步的肝靶向药物控释的研究奠定了基础.

关键词: 甘草次酸, 壳聚糖, 肝靶向

Abstract: Chitosan derivative with glycyrrhetinic acid(GA), which was accumulated specifically in liver, was synthesized. By ion-crosslinking of TPP in GA-CTS solution, GA-CTS-TPP complex nanoparticles were obtained. The physicochemical properties of these nanoparticles were investigated by using TEM and DLS. The experiment in vitro BSA entrapped was studied. GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.

Key words: Glycyrrhetinic acid, Chitosan, Liver targeting

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