高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (1): 173.doi: 10.7503/cjcu20180351

• 高分子化学 • 上一篇    下一篇

改性壳聚糖抗菌纳米微球的制备

殷茂力, 王英沣, 任学宏()   

  1. 江南大学纺织服装学院, 生态纺织教育部重点实验室, 无锡 214122
  • 收稿日期:2018-05-11 出版日期:2019-01-10 发布日期:2018-10-16
  • 作者简介:

    联系人简介: 任学宏, 男, 博士, 教授, 博士生导师, 主要从事高效抗菌剂的合成和抗菌纺织品、 纺织品功能整理, 纳米结构生物抗菌纤维、 纺织纤维和高分子材料改性研究. E-mail: xhren@jiangnan.edu.cn

  • 基金资助:
    国家自然科学基金(批准号: 21706093)和江苏省研究生科研创新计划项目(批准号: KYCX18-1833)资助.

Preparation of Modified Chitosan Antibacterial Nanospheres

YIN Maoli, WANG Yingfeng, REN Xuehong*()   

  1. College of Textiles and Clothing, Key Laboratory of Eco-textiles, Ministry of Education, Wuxi 214122, China
  • Received:2018-05-11 Online:2019-01-10 Published:2018-10-16
  • Contact: REN Xuehong E-mail:xhren@jiangnan.edu.cn
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No. 21706093) and the Graduate Student Innovation Plan of Jiangsu Province, China(No. KYCX18-1833).

摘要:

以卤胺化合物为抗菌基团对壳聚糖接枝改性, 并制备成纳米微球, 提高壳聚糖的抗菌性能. 通过核磁共振和紫外光谱对改性壳聚糖进行结构表征; 探讨了改性壳聚糖浓度、 三聚磷酸钠浓度及两者体积比对纳米微球的形成和粒径分布的影响; 测定了纳米微球的抗菌性能. 结果表明, 在改性壳聚糖浓度为4.0 mg/mL, 三聚磷酸钠浓度为2.0 mg/mL时, 形成的纳米微球形态稳定, 粒径分布均匀, 氯化后的纳米微球可在30 min内杀灭107 cfu(cfu为单位体积中的菌落总数)的金黄色葡萄球菌和大肠杆菌, 表现出优异的抗菌性能.

关键词: 壳聚糖, 卤胺化合物, 纳米微球, 抗菌性能

Abstract:

A novel antibacterial nanospheres was prepared by modification of chitosan with N-halamine, and characterized by nuclear magnetic resonance(NMR) and ultraviolet spectrum(UV). The effect of concentration and volume ratio of CS-HDH, polysodium tripolyphosphate(TPP) and the volume ratio of the two polymers on the formation and particle size of nanoparticles were discussed. The antibacterial properties were also measured. The results show that the nanospheres has a stable shape and uniform distribution of particle size. Excellent antibacterial properties can be obtained, and 107 cfu(colong-forming units) of S. aureus and E. coli can be killed within 30 min.

Key words: Chitosan, N-Halamine, Nanospheres, Antibacterial

中图分类号: 

TrendMD: