高等学校化学学报

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (4): 784.

• 研究简报 • 上一篇    下一篇

两亲性三嵌段共聚物PAA-PHB-PAA的合成及表征

张雪勤1, 郑云1, 杨琥1, 刘全伟1, 谢鸿峰1, 王治流1, 程镕时1,2   

  1. 1. 南京大学化学化工学院介观化学教育部重点实验室, 高分子科学与工程系, 南京 210093;
    2. 华南理工大学材料学学院高分子研究所, 广州 510640
  • 收稿日期:2005-06-10 出版日期:2006-04-10 发布日期:2006-04-10
  • 通讯作者: 程镕时(1927年出生), 男, 教授, 博士生导师， 中国科学院院士, 主要从事高分子溶液及高分子凝聚态物理研究. E-mail: rscheng@nju.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20204004, 20474026)和教育部博士学科点基金(批准号: 20030284003)资助.

Synthesis and Characterization of Amphiphilic Triblock Copolymers PAA-PHB-PAA

ZHANG Xue-Qin1, ZHENG Yun1, YANG Hu1, LIU Quan-Wei1,XIE Hong-Feng1, WANG Zhi-Liu1, CHENG Rong-Shi1,2*   

  1. 1. Key Laboratory for Mesoscopic Chemistry of Ministry of Education, Department of Polymer Science & Engineering, College of Chemistry & Chemcal Engineering, Nanjing University, Nanjing 210093, China;
    2. Polymer Institute,  College of Material Science and Engineering, South China University of Technology, Guangzhou 510640, China
  • Received:2005-06-10 Online:2006-04-10 Published:2006-04-10
  • Contact: CHENG Rong-Shi, E-mail: rscheng@nju.edu.cn

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被引次数

13

摘要：

本文用ATRP方法, 以两端溴化的聚β-羟基丁酸酯链段(Br-PHB-Br)作为大分子引发剂, 丙烯酸叔丁酯为单体, 合成了一种新的三嵌段共聚物聚丙烯酸叔丁酯-聚β-羟基丁酸酯-聚丙烯酸叔丁酯(PtBA-PHB-PtBA). 在酸性条件下进一步水解, 得到了一种两亲性的聚丙烯酸-聚β-羟基丁酸酯-聚丙烯酸(PAA-PHB-PAA)三嵌段共聚物.

关键词: 原子转移自由基聚合(ATRP); 两亲性三嵌段共聚物; 合成; 表征

Abstract:

A new biodegradable PtBA-PHB-PtBA triblock copolymer was successfully synthesized by ATRP method with Br-PHB-Br as macroinitiator, tert-butyl acrylate as monomer and CuBr/PMDETA as the catalyst system. Cleavage of the tert-butyl ether groups of the PtBA-PHB-PtBA triblock copolymer was then performed via hydrolysis with trifluoroacetic acid as the catalyst in dichloromethane to afford the amphiphilic PAA-PHB-PAA triblock copolymer. The hydrolysis is successful but trace tert-butyl ether groups still remain in the backbone. The molecular weight characteristics and chain structures were conformed by GPC and NMR, respectively. Because of hydrophilic and biocompatibility, the amphiphilic triblock copolymers have potential applications in the field of drug release.

Key words: Atom transfer radical polymerization; Amphiphilic triblock copolymer;  Synthesis; Characterization

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