高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (12): 2779-2783.doi: 10.7503/cjcu20120534

• 高分子化学 • 上一篇    下一篇

基于天然高分子基元的阻隔层对磁性载药聚乳酸微球的控释作用

付昱2, 杨敏3, 李妍2, 仲崇斌2, 焦永华2, 林奥雷1   

  1. 1. 吉林大学超硬材料国家重点实验室, 长春 130012;
    2. 东北大学理学院, 沈阳 110004;
    3. 北京卫生职业学院, 北京100053
  • 收稿日期:2012-06-04 出版日期:2012-12-10 发布日期:2012-11-20
  • 通讯作者: 林奥雷,男,博士,副研究员,主要从事高分子材料研究.E-mail:linal@jlu.edu.cn E-mail:linal@jlu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20974017, 21174024, 50174014)、 辽宁省自然科学基金(批准号: 20102075)和中央高校基本科研业务费(批准号: N100405006)资助.

Effect of Layer-by-layer Films of Natural Polymers on Drug Release of Magnetic Poly(lactic acid) Microspheres

FU Yu2, YANG Min3, LI Yan2, ZHONG Chong-Bin2, JIAO Yong-Hua2, LIN Ao-Lei1   

  1. 1. State Key Laboratory of Superhard Materials, Jilin University, Changchun 130012, China;
    2. College of Sciences, Northeastern University, Shenyang 110004, China;
    3. Beijing Health School, Beijing 100053, China
  • Received:2012-06-04 Online:2012-12-10 Published:2012-11-20
  • Contact: LIN AoLei E-mail:linal@jlu.edu.cn

摘要:

利用层层组装技术构建了基于天然高分子壳聚糖和海藻酸钠的阻隔层, 并研究了该阻隔层对磁性载药聚乳酸微球的药物释放作用. 实验结果表明, 阻隔层能够有效抑制模型药物的突释, 具有延缓药物释放的效果. 具有阻隔层的磁性载药体系具有药物释放平缓和生物相容性高等特点, 是理想的磁靶向载药体系.

关键词: 聚乳酸微球, 磁性纳米粒子, 层层自组装, 药物缓释

Abstract:

Polylactic acid(PLA) microsphere is an ideal drug carrier with high tolerance to the human body and the capability of carrying a wide range of drugs. However, the burst release of drug from the drug-loaded microspheres limit its effective application. Constructing a barrier layer at the surface of microspheres is an effective way to control the burst release of drug. A barrier layer consisting of natural polymer chitosan and sodium alginate was constructed by employing the layer-by-layer assembly technology. Furthermore, the effect of the layer on the drug release from magnetic PLA microsphere was investigated. The experimental results demonstrated that the barrier layer could effectively restrain the burst release of model drug, thus delaying the drug release. The magnetic drug delivery system constructed in this study is a promising magnetic targeted drug delivery system which allows the sustained release of drug and has high biocompatibility.

Key words: Poly(lactic acid) microsphere, Magnetic nanoparticles, Layer-by-layer self-assembly, Sustained-release of drug

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