高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (4): 680.

• 研究简报 • 上一篇    下一篇

以壳聚糖为载体的内毒素吸附剂

王慧彦1, 侯光辉1, 俞玫1, 袁直1, 刘斌2, 赵承梅2   

  1. 1. 吸附分离功能高分子材料国家重点实验室, 南开大学高分子化学研究所, 天津 300071;
    2. 天津医学高等专科学校, 天津 300052
  • 收稿日期:2004-05-11 出版日期:2005-04-10 发布日期:2005-04-10
  • 通讯作者: 袁 直(1961年出生),女,教授,博士生导师,从事生物医用高分子材料研究.E-mail:zhiy@nankai.edu.cn E-mail:zhiy@nankai.edu.cn
  • 基金资助:

    国家“九七三”计划(批准号:G1999064707);国家自然科学基金(批准号:50373021);博士学科点基金(批准号:20030055038);南开大学科技创新基金资助.

Adsorbents for Endotoxin Based on Chitosan Matrix

WANG Hui-Yan1, HOU Guang-Hui1, YU Mei1, YUAN Zhi1, LIU Bin2, ZHAO Cheng-Mei2   

  1. 1. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;
    2. Tianjin Medical College, Tianjin 300052, China
  • Received:2004-05-11 Online:2005-04-10 Published:2005-04-10

关键词: 壳聚糖, 内毒素, 吸附剂, 血液灌流

Abstract: The endotoxin adsorbents were prepared by coupling divinyl amine ligands on crosslinked chitosan matrix. Their adsorption ability to endotoxin was compared. It was found that the adsorbent with polyethylene polyamine ligand had the highest adsorption capacity and its clearance percent for endotoxin in endotoxemia plasma was over 80. The results also showed that the adsorbent has good blood compatibility and clinical application foreground.

Key words: Chitosan, Endotoxin, Adsorbent, Hemoperfusion.

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