高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (4): 642.

• 研究论文 • 上一篇    下一篇

分子印迹-化学发光分析法测定安乃近

何云华, 吕九如, 张红鸽, 杜建修   

  1. 陕西师范大学化学与材料科学学院, 西安 710062
  • 收稿日期:2004-05-19 出版日期:2005-04-10 发布日期:2005-04-10
  • 通讯作者: 吕九如(1944年出生),男,教授,博士生导师,从事发光分析研究.E-mail:ljr@snnu.edu.cn E-mail:ljr@snnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:20275023);陕西省自然科学基金(批准号:2002B12)资助.

Molecular Imprinting-{chemiluminescence} Determination of Analgin

HE Yun-Hua, LV Jiu-Ru, ZHANG Hong-Ge, DU Jian-Xiu   

  1. School of Chemistry and Material, Shaanxi Normal University, Xi'an 710062, China
  • Received:2004-05-19 Online:2005-04-10 Published:2005-04-10

PDF (PC)

被引次数

40

摘要： 以甲基丙烯酸为功能单体,乙二醇二甲基丙烯酸酯为交联剂,合成了安乃近分子印迹聚合物,对其性能进行了Scatchard分析;以此聚合物为分子识别物质,利用锰(Ⅱ)-甲醛-安乃近化学发光体系,结合流动分析技术,建立了高选择性测定安乃近的分子印迹-化学发光分析方法.该方法的线性范围为1.0×10-7～1.0×10-5mol/L,检出限为4×10-8mol/L,对1.0×10-6mol/L安乃近溶液平行测定7次的相对标准偏差为2.4.该方法已用于尿液中安乃近的直接测定.

关键词: 化学发光, 分子印迹, 安乃近, 锰(Ⅳ)

Abstract: Chemiluminescence(CL) reaction of manganese(Ⅳ)-formaldehyde-analgin was carried out. Molecular imprinted polymer of analgin was prepared by using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The binding characteristic of the analgin-imprinted polymer was evaluated by Scatchard analysis. A new chemiluminescence method for the determination of analgin was proposed by the combination of analgin-imprinted polymer and manganese(Ⅳ)-formaldehyde-analgin CL system. The linear range is 1.0×10-7 -1.0×10-5 mol/L, the detection limit is 4×10-8 mol/L, the relative standard deviation is 2.4(1.0×10-6 mol/L analgin, n=7 ). The method was applied to the determination of analgin in human urine samples directly.

Key words: Chemiluminescence, Molecular imprinting, Analgin, Manganese(Ⅳ)

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