高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (1): 175.

• 研究论文 • 上一篇    下一篇

溶液喷丝法制备组织工程无纺布支架

刘厚利1, 陈金武2, 王连才1, 王常勇2, 冯增国1   

  1. 1. 北京理工大学材料科学与工程学院,北京 100081;
    2. 军事医学科学院基础医学研究所组织工程中心,北京 100850
  • 收稿日期:2003-11-04 出版日期:2005-01-10 发布日期:2005-01-10
  • 通讯作者: 冯增国(1957年出生),男,研究员,博士生导师,从事生物医用材料研究.E-mail:sainfeng@bit.edu.cn E-mail:sainfeng@bit.edu.cn
  • 基金资助:

    北京市科委科研项目(批准号:H020920040330)资助

Preparation of PEGT/PBT Tissue Engineering Scaffolds by Solution Spray Method

LIU Hou-Li1, CHEN Jin-Wu2, WANG Lian-Cai1, WANG Chang-Yong2, FENG Zeng-Guo1   

  1. 1. School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081, China;
    2. Tissue Engineering Research and Development Center, Beijing Institute of Basic Medical Sciences, Academy Military Medical Science, Beijing 100850, China
  • Received:2003-11-04 Online:2005-01-10 Published:2005-01-10

PDF (PC)

被引次数

5

摘要： 在高压氮气作用下用溶液喷丝制备了组织工程支架.聚乙二醇/聚对苯二甲酸丁二醇酯(PEGT/PBT)共聚物的氯仿溶液经高压氮气流喷丝,继而沉积成无纺布.为了提高支架的生物相容性,将透明质酸水溶液喷涂到PEGT/PBT丝表面.结果表明,所制备的支架材料的生物相容性良好,细胞外基质透明酸能显著提高无纺布支架的生物相容性.

关键词: 溶液喷丝, 聚乙二醇/聚对苯二甲酸丁二醇酯, 组织工程, 无纺布支架, 生物相容性

Abstract: A novel method for solution spray at a high nitrogen pressure was applied in the preparation of tissue engineering scaffolds. The chloroform solution of biodegradable poly(ether ester) poly(ethylene glycol terephthalate)/poly(butylene terephthalate)(PEGT/PBT) was nebulized to give fibers in the nitrogen current and subsequently to accumulate into non-woven scaffolds. At the same time, the hyaluronic acid(HA) aqueous solution was sprayed onto the surface of the resulted fibers to form more biocompatible scaffolds. The implant experiments indicated that these scaffolds were perfect in biocompatibility. HA used as an extracellular matrix improved the biocompatibility of the non-woven scaffolds.

Key words: Solution spray, PEGT/PBT, Tissue engineering, Non-woven scaffold, Biocompatibility

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