高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (7): 1409-1415.doi: 10.7503/cjcu20150231

• 高分子化学 • 上一篇    下一篇

聚乳酸组织工程支架结构的精密调控

薛丽1, 聂涛涛1, 马海云1,2()   

  1. 1. 河北大学化学与环境科学学院, 2. 河北省分析科学技术重点实验室, 保定 071002
  • 收稿日期:2015-03-23 出版日期:2015-07-10 发布日期:2015-06-05
  • 作者简介:联系人简介: 马海云, 男, 博士, 副教授, 主要从事高分子纳米材料研究. E-mail:coffee1123@126.com
  • 基金资助:
    河北省自然科学青年基金(批准号: E2013201230)、 高等学校博士学科点专项科研基金(新教师类)(批准号: 20131301120006)和教育部留学回国人员科研启动基金资助

Precise Structural Regulation of Poly(L-lactide) Acid Tissue Engineering Scaffolds

XUE Li1, NIE Taotao1, MA Haiyun1,2,*()   

  1. 1.College of Chemistry & Environmental Science, Hebei University, 2. Key Laboratory of Analytical Science and Technology of Hebei Province, Baoding 071002, China
  • Received:2015-03-23 Online:2015-07-10 Published:2015-06-05
  • Contact: MA Haiyun E-mail:coffee1123@126.com
  • Supported by:
    † Supported by the Natural Science Foundation of Hebei Province of China(No;E2013201230), the Research Fund for the Doctoral Program of Higher Education of China(No.20131301120006) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, China

摘要:

采用糖球模板法结合热致相分离技术, 制备了孔径尺寸、 内连通度及孔隙率高度可控的左旋聚乳酸(PLLA)支架材料, 并通过扫描电镜(SEM)、 红外光谱(FTIR)以及示差扫描量热法(DSC)对其空间结构及性能进行了系统研究. 支架材料孔径从50 μm到800 μm及内连通孔径从10 μm到200 μm连续可调, 微观孔壁结构根据不同溶剂可形成各异的微纳米结构. 支架的制备对PLLA化学结构无显著影响, 但相分离过程会不同程度地降低PLLA的结晶度.

关键词: 聚乳酸组织工程支架, 糖球模板, 热致相分离

Abstract:

A thermal induced phase separation combined sugar template method was used to fabricate the poly(L-lactide) acid(PLLA) scaffolds with a highly controllable inner spatial structure including pore size, inner connectivity and porosity. Scanning electron microscope(SEM), Fourier transform infrared spectroscopy(FTIR) and differential scanning calorimetry(DSC) were used to investigate the spatial structure and property of the PLLA scaffolds. The scaffolds obtained consist of adjustable micro-pores with diameter ranging from 50 μm to 800 μm and inner pore diameter ranging from 10 μm to 200 μm. Different micro- and nano-structures were formed by different solvent systems. The chemical structure of scaffold was little affected by the fabrication method. The crystallinity degree decreased on different levers after phase separation.

Key words: Poly(L-lactide) acid tissue engineering scaffold, Sugar sphere template, Thermal induced phase separation

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