高等学校化学学报

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (9): 1673.

• 研究简报 • 上一篇    下一篇

含有异噁唑的S-三唑[3,4-b]-1,3,4-噻二嗪、咪唑[2,1-b]-1,3,4-噻二唑和咪唑[2,1-b]-1,3,4-噁二唑衍生物的合成

刘方明1,2, 阿布拉江·克依木3, 王厚勇2, 邵玲2   

  1. 1. 杭州师范学院化学系, 杭州310012;
    2. 新疆大学化学与化工学院, 乌鲁木齐830046;
    3. 中国医学科学院中国协和医科大学药物研究所, 北京100050
  • 收稿日期:2003-08-04 出版日期:2004-09-24 发布日期:2004-09-24
  • 基金资助:

    国家自然科学基金(批准号:29702007,20162004)资助

Synthesis of S-Triazolo-1,3,4-thiadiazine, Imidazolo- 1,3,4-thiadiazole and Imidazolo-1,3,4-oxadiazole Derivatives Containing Isoxazole

LIU Fang-Ming1,2, ABLAJAN Keyume3, WANG Hou-Yong2, SHAO Ling2   

  1. 1. Department of Chemistry, Hangzhou Teacher College, Hangzhou 310012, China;
    2. College of Chemistry and Chemical Engineering, Xinjiang University, Ulumuqi 830046, China;
    3. Institute of Materia Medica, CA MS & PU MC, Beijing 100050, China
  • Received:2003-08-04 Online:2004-09-24 Published:2004-09-24

PDF (PC)

被引次数

16

关键词: 异噁唑, 均三唑并噻二嗪, 咪唑[2, 1-b]-1, 3, 4-噻二唑, 咪唑[2, 1-b]-1, 3, 4-噁二唑

Abstract: Isoxazole derivatives were characterized by broad spectrum of biological activities, but the condensed heterocyclic compounds containing isoxazole were scarcely reported. In this paper, we studied the 1,3-dipolar cycloaddition of p-methoxybenzohydroxamoyl chloride with ethyl sodioacetoacetate to obtain a key intermediate 2. Through compound 2, fifteen novel S-triazolo-1,3,4-thiadiazines(5a-5e), imidazolo-1,3,4-thiadiazoles(9a-9e) and imidazolo-1,3,4-oxadiazoles(10a-10e) containing isoxazole, which have potentially useful biological activities, were synthesized. The structures of the products were confirmed by elemental analyses and spectral analysis. And the characteristic data of IR, 1H NMR and MS were explained reasonably.

Key words: Isoxazole, S-Triazolo-1,3,4-thiadiazine, Imidazolo-1,3,4-thiadiazole, Imidazolo-1,3,4-oxadiazole

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