高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (8): 1582.

• 研究简报 • 上一篇    

两亲性寡聚体Gd(Ⅲ)配合物的合成及肝选择性磁共振造影

柏正武1,3, 俞开潮2, 卓仁禧3   

  1. 1. 武汉化工学院化工与制药系, 武汉430073;
    2. 中国科学院武汉物理与数学研究所, 武汉430071;
    3. 武汉大学化学系, 武汉430072
  • 收稿日期:2003-08-21 出版日期:2004-08-24 发布日期:2004-08-24
  • 基金资助:

    国家自然科学基金(批准号:29874028)资助

Preparation of Amphiphilic Oligomers of Gd(Ⅲ) Complexes and Their Liver-selective MRI Property

BAI Zheng-Wu1,3, YU Kai-Chao2, ZHUO Ren-Xi3   

  1. 1. Department of Chemical Engineering and Pharmaceutics, Wuhan Institute of Chemical Technology, Wuhan 430073, China;
    2. Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China;
    3. Department of Chemistry, Wuhan University, Wuhan 430072, China
  • Received:2003-08-21 Online:2004-08-24 Published:2004-08-24

关键词: 两亲性, 三元寡聚体配体, Gd配合物, 肝选择性磁共振造影

Abstract: Diethylenetriaminepentaacetic dianhydride was co-polymerized with dodecyl ester and benzyl ester of lysine,and octodecyl ester and benzyl ester of lysine respectively to give two terpolymers. These two terpolymer ligands were reacted with GdCl3 to afford amphiphilic oligomers of Gd(Ⅲ) complexes. These new ligands and Gd(Ⅲ) complexes were characterized by IR, 1H NMR and elemental analysis. The oligomeric complexes show a higher relaxivity as compared to that of Gd(DTPA) which is widely used in clinic diagnoses. The Gd(Ⅲ) complex derived from octodecyl ester demonstrated liver-selective enhancement for MR imaging of Wistar rat. The ratios of signal to noise ( S/N ) in the proton intensity imaging were enhanced,respectively,by 15%,27%,and 36% at the time of 5,30 and 45 min after injection of this complex.

Key words: Amphiphilicity, Oligomeric terpolymer ligand, Gd(Ⅲ) complex, Liver-selective MR imaging

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