改性海藻酸钠活化SiO2纳米粒子稳定载药Pickering乳液及释药性

doi:10.7503/cjcu20130299

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (9): 2164.doi: 10.7503/cjcu20130299

改性海藻酸钠活化SiO₂纳米粒子稳定载药Pickering乳液及释药性

颜慧琼¹, 李嘉诚¹, 冯玉红¹, 胡文涛¹, 刘若林¹, 林强^1,2

1. 海南大学材料与化工学院化学系, 海口 570228;
2. 海南师范大学化学化工学院化学系, 海口 571100

收稿日期:2013-04-01 出版日期:2013-09-10 发布日期:2013-08-30
作者简介:林强,男,博士,教授,博士生导师.主要从事精细化学品分子设计、化工工艺、有机合成和生物材料方面的研究.E-mail:linqiang@hainu.edu.cn
基金资助:
国家“十二五”科技支撑计划项目(批准号:2011BAE06A06-7,2011BAEO6B04-7);海南省重点科技计划项目(批准号:ZDXM20120003);海口市重点科技计划项目(批准号:2011-0104)资助.

Stability and Release Properties of Drug-loaded Pickering Emulsions by the Modified Sodium Alginate Activated SiO₂ Nanoparticles

YAN Hui-Qiong¹, LI Jia-Cheng¹, FENG Yu-Hong¹, HU Wen-Tao¹, LIU Ruo-Lin¹, LIN Qiang^1,2

1. Department of Chemistry, College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China;
2. Department of Chemistry, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571100, China

Received:2013-04-01 Online:2013-09-10 Published:2013-08-30

摘要/Abstract

摘要：

以胆固醇疏水改性两亲性海藻酸钠衍生物表面, 活化SiO₂纳米粒子, 再制得负载氯氟氰菊酯的O/W型Pickering乳液. 通过傅里叶变换红外光谱(FTIR), 氢核磁共振波谱(¹H NMR)、荧光光谱、动态光散射、光学显微镜和释药实验分别对海藻酸钠衍生物和Pickering乳液的性能进行了表征. 结果表明, 胆固醇基接枝到了海藻酸钠分子链上, 改性后的海藻酸钠临界聚集浓度由1.26 mg/L降为0.28 mg/L, 表现出了良好的两亲性. 将海藻酸钠衍生物(CSAD)和表面活性剂十六烷基三甲基溴化铵(CTAB)吸附于SiO₂纳米粒子表面, 得到活化SiO₂纳米粒子, 其Zeta电位分别为-30.7和16.4 mV, 粒径分别增大到583.3和438.4 nm. 由CSAD活化SiO₂粒子制备的乳液释药速率更缓慢. CSAD的交联作用使吸附于油水界面的活化SiO₂粒子形成了比较稳定的网络结构或界面膜.

关键词: 氯氟氰菊酯, 海藻酸钠, 胆固醇, 两亲性, Pickering乳液, SiO₂纳米粒子, 海藻酸钠衍生物

Abstract:

Pickering emulsions(W/O) loaded cyhalothrins were prepared by SiO₂ nanoparticles whose surface were activated using amphiphilic alginate derivative hydrophobically modified by cholesterol under the conditions of high speed stirring. And they were characterized by means of Fourier transform infrared spectroscopy(FTIR),¹H nuclear magnetic resonance(¹H NMR), fluorescence spectrum, dynamic light scattering, optical microscope and release studies. Experimental results showed that cholesterol groups had successfully grafted to the alginate molecular chains. The critical aggregation concentration of modified alginate was reduced from 1.26 mg/L to 0.28 mg/L, which showed good amphipathy. Alginate derivative(CSAD) and surfactant CTAB could be also adsorbed on the surface of SiO₂ nanoparticles with the corresponding zeta potential which were 16.4 and -30.7 mV, respectively. And the particle sizes were 583.3 and 438.4 nm, respectively. The release rate of the Pickering emulsions prepared by the SiO₂ particles activated by CSAD was more slowly. That may be the cross-linking action of CSAD which made the activated SiO₂ particles adsorbed on the oil-water interface form the relatively stable network structures or the interface membranes.

Key words: Cyhalothrin, Sodium alginate, Cholesterol, Amphipathic, Pickering emulsion, SiO₂ nano-particles, Cholesteryl grafted sodium alginate derivative(CSAD)

中图分类号:

TrendMD:

颜慧琼, 李嘉诚, 冯玉红, 胡文涛, 刘若林, 林强. 改性海藻酸钠活化SiO₂纳米粒子稳定载药Pickering乳液及释药性. 高等学校化学学报, 2013, 34(9): 2164.

YAN Hui-Qiong, LI Jia-Cheng, FENG Yu-Hong, HU Wen-Tao, LIU Ruo-Lin, LIN Qiang. Stability and Release Properties of Drug-loaded Pickering Emulsions by the Modified Sodium Alginate Activated SiO₂ Nanoparticles. Chem. J. Chinese Universities, 2013, 34(9): 2164.

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改性海藻酸钠活化SiO₂纳米粒子稳定载药Pickering乳液及释药性

Stability and Release Properties of Drug-loaded Pickering Emulsions by the Modified Sodium Alginate Activated SiO₂ Nanoparticles

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