高等学校化学学报 ›› 2016, Vol. 37 ›› Issue (5): 1018-1024.doi: 10.7503/cjcu20150831

• 高分子化学 • 上一篇    

基于Ugi多组分反应的海藻酸酰胺衍生物改性二氧化硅纳米粒子的制备

颜慧琼1, 陈秀琼1, 李嘉诚2(), 冯玉红2, 伍剑博2, 林强1(), 史载峰1, 王向辉1   

  1. 1. 海南师范大学化学化工学院, 海口 571158
    2. 海南大学材料与化工学院, 海口 570228
  • 收稿日期:2015-10-30 出版日期:2016-05-10 发布日期:2016-04-21
  • 作者简介:联系人简介: 林 强, 男, 博士, 教授, 博士生导师, 主要从事精细化学品分子设计、 化工工艺、 有机合成和生物材料方面的研究. E-mail:linqianggroup@163.com
    李嘉诚, 男, 博士, 教授, 主要从事胶体界面化学方面的研究. E-mail: ljcfyh@263.net
  • 基金资助:
    国家自然科学基金 (批准号: 21366010, 21566009)和海南省重点科技计划项目(批准号: ZDXM2014037)资助

Synthesis of Amidic Alginate Derivatives Modified Silica Nanoparticles via Ugi Multicomponent Reaction

YAN Huiqiong1, CHEN Xiuqiong1, LI Jiacheng2,*(), FENG Yuhong2, WU Jianbo2, LIN Qiang1,*(), SHI Zaifeng1, WANG Xianghui1   

  1. 1. College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China
    2. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China
  • Received:2015-10-30 Online:2016-05-10 Published:2016-04-21
  • Contact: LI Jiacheng,LIN Qiang E-mail:ljcfyh@263.net;linqianggroup@163.com
  • Supported by:
    † Supported by the National Natural Science Foundation of China(Nos.21366010, 21566009) and the Key Projects in the Hainan Provincial Science & Technology Program, China(No.ZDXM2014037)

摘要:

采用海藻酸酰胺衍生物通过Ugi多组分反应制备了新颖的聚合物-二氧化硅(Oct-Alg-SiO2)纳米粒子. 通过氢核磁共振波谱(1H NMR)和X射线光电子能谱(XPS)对Oct-Alg-SiO2的结构和表面元素组分进行了表征. 采用透射电子显微镜(TEM)、 Zeta电位和激光粒度分析仪对Oct-Alg-SiO2的形貌、 粒径和胶体性能进行了探索. 结果表明, 海藻酸酰胺衍生物共价接枝到氨基二氧化硅(SiO2-NH2)纳米粒子的表面, 提高了其平均直径, 调控了其Zeta电位, 在水介质中能够表现出良好的分散稳定性. 以10%的液体石蜡为油相, 采用Oct-Alg-SiO2制备了Pickering乳液. 在油水界面能够形成液滴粒径为5.7 μm的稳定Pickering乳液. 随着水相pH值的增大, 乳液体积分数增大, 稳定性增强. 细胞相容性实验结果表明, Oct-Alg-SiO2纳米粒子具有极好的生物相容性.

关键词: Ugi多组分反应, 二氧化硅纳米粒子, 两亲性, Pickering乳液, 海藻酸酰胺衍生物

Abstract:

To wider applications of silica(SiO2) nanoparticles, the Ugi multicomponent reaction was proposed to prepare the novel polymers-silica(Oct-Alg-SiO2) nanoparticles using amidic alginate derivatives. The structure and surface elemental composition of Oct-Alg-SiO2 were confirmed by 1H Nuclear Magnetic Resonance(1H NMR) spectrometer and X-ray photoelectron spectroscopy(XPS). Additionally, the morpho-logy, size and colloid stability of Oct-Alg-SiO2 were also investigated via transmission electron microscope(TEM), zeta potential and laser particle size analyzer. The characterization of the materials revealed that Oct-Alg-SiO2 nanoparticles were successfully fabricated via the Ugi reaction. The amidic alginate derivatives were covalently bonded onto the surface of amino-functionalized silica(SiO2-NH2) nanoparticles, increasing their average diameter and tuning their zeta potential, which could exhibit good dispersion stability performance in the aqueous media. The Pickering emulsions were prepared by Oct-Alg-SiO2 using 10% liquid paraffin as the oil phase. It is worth noting that the stable Pickering emulsions with an average size of 5.7 μm could form between the oil-water interfaces. With the increase of pH value, the volume fraction of the emulsions increased and the stability of the emulsions also improved. The cytocompatibility experimental results showed that Oct-Alg-SiO2 nanoparticles possessed excellent biocompatibility. Oct-Alg-SiO2 nanoparticles combined excellent colloid stability performance of SiO2 nanoparticles and good biological properties of amidic alginate derivatives, possessing great potentials in biomedical applications.

Key words: Ugi multicomponent reaction, Silica nanoparticles, Amphipathic, Pickering emulsions, Amidic alginate derivatives

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